628340-27-2

Upstream product

• 628340-26-1 3-benzoyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-4-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 872997-50-7 3-benzoyloxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 872997-48-3 3-hydroxy-2-hydroxymethyl-4-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 872997-47-2 2,2,7-trimethyl-tetrahydro-[1,3]dioxino[5,4-b]pyrrole-5-carboxylic acid tert-butyl ester 
• 872997-45-0 [4-(2-hydroxy-1-methyl-ethyl)-2,2-dimethyl-[1,3]dioxan-5-yl]-carbamic acid tert-butyl ester 
• 872997-49-4 2-(tert-butyl-dimethyl-silanyloxymethyl)-3-hydroxy-4-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 872997-46-1 toluene-4-sulfonic acid 2-(5-tert-butoxycarbonylamino-2,2-dimethyl-[1,3]dioxan-4-yl)-propyl ester 
• 102308-32-7 (4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 876856-86-9 ((1S,2R,3R)-2-Hydroxy-1-hydroxymethyl-3-methyl-pent-4-enyl)-carbamic acid tert-butyl ester 
• 220317-65-7 [(4R,5S)-2,2-Dimethyl-4-((R)-1-methyl-allyl)-[1,3]dioxan-5-yl]-carbamic acid tert-butyl ester 
• 140630-93-9 (S)-4-((1R,2R)-1-Hydroxy-2-methyl-but-3-enyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 556834-59-4 4-methyl-5-phenylsulfanyl-(Z,4S)-2-penten-1-ol 
• 556834-58-3 methyl 4-methyl-5-phenylsulfanyl-(Z,4S)-2-pentenoate 
• 628340-20-5 4-methyl-5(RS_S)-phenylsulfinyl-(Z,4S)-2-penten-1-ol 

Relevant academic research and scientific papers

Asymmetric synthesis of (2R,3R,4R)-3-hydroxy-4-methyl-propline via chromium(II) chloride-mediated coupling reactions of (S)-garner aldehyde with crotyl bromide

Efficient synthesis of (2R,4R,4R)-3-hydroxy-4-methylproline (1a), which is an antipode of the component of potent antifungal echinocandins, from (S)-Garner aldehyde (2a) has been established. The key step is chromium(II) chloride-mediated coupling reactio

Practical, efficient, stereoselective, formal synthesis of (2R,3R,4R)-3-hydroxy-4-methylproline

A highly efficient and stereoselective synthesis of (2R,3R,4R)-HMP is disclosed employing the sulfinyl group as an internal nucleophile to functionalize an olefin in the key step of the reaction sequence. The proline ring is elaborated by a (4C+N) cycliza