872997-46-1

Upstream product

• 872997-45-0 [4-(2-hydroxy-1-methyl-ethyl)-2,2-dimethyl-[1,3]dioxan-5-yl]-carbamic acid tert-butyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 876856-86-9 ((1S,2R,3R)-2-Hydroxy-1-hydroxymethyl-3-methyl-pent-4-enyl)-carbamic acid tert-butyl ester 
• 220317-65-7 [(4R,5S)-2,2-Dimethyl-4-((R)-1-methyl-allyl)-[1,3]dioxan-5-yl]-carbamic acid tert-butyl ester 
• 140630-93-9 (S)-4-((1R,2R)-1-Hydroxy-2-methyl-but-3-enyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 102308-32-7 (4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 

Downstream Products

• 628340-27-2 (2S,3R,4R)-3-Benzoyloxy-2-hydroxymethyl-4-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 872997-50-7 3-benzoyloxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Asymmetric synthesis of (2R,3R,4R)-3-hydroxy-4-methyl-propline via chromium(II) chloride-mediated coupling reactions of (S)-garner aldehyde with crotyl bromide

Efficient synthesis of (2R,4R,4R)-3-hydroxy-4-methylproline (1a), which is an antipode of the component of potent antifungal echinocandins, from (S)-Garner aldehyde (2a) has been established. The key step is chromium(II) chloride-mediated coupling reactio