62868-24-0

Upstream product

• 109-99-9 tetrahydrofuran 
• 1848-69-7 1-phenylimidazolidin-2-one 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 1020536-55-3 N-(3-ethynylphenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide 
• 1020535-62-9 N-(3-fluoro-4-(2-(pyrrolidine-1-carboxamido)pyridin-4-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide 
• 1020535-60-7 N-(3-fluoro-4-(6-(pyrrolidine-1-carboxamido)pyrimidin-4-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide 
• 1020536-61-1 N-(3-fluoro-4-(3-iodopyridin-4-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide 
• 1020536-27-9 N-(4-(N-(6-acetamidopyridin-3-yl)sulfamoyl)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide 
• 1020536-30-4 N-(3-fluoro-4-(6-oxo-1,6-dihydropyridin-3-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide 
• 1020536-52-0 N-(3-(6-nitropyridin-3-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide 

Relevant academic research and scientific papers

KINASE INHIBITORS AND USES THEREOF

The present invention relates to compounds of the general formula (A) and pharmaceutical compositions thereof that inhibit protein tyrosine activity. In particular the invention relates to said compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signalling, for example, the inhibition of VEGF receptor signalling and HGF receptor signalling. Said compounds and compositions are useful for the treatment of cell proliferative diseases and conditions.

Oxo-imidazolidine substituted cephalosporins and antibacterial compositions and methods of combatting bacteria employing them

Cephalosporins of the formula STR1 their pharmaceutically-acceptable, nontoxic salts, and hydrates thereof are produced, wherein A is hydrogen; unsubstituted or substituted alkyl; aryl; or R1 --X--, wherein X is --CO-- or --SO2 --, and R1 is hydrogen, unsubstituted or substituted alkyl; aryl; thienyl; furyl; amino; alkylamino; dialkylamino; pyrrolidyl; or piperidyl; Or when X is --CO--, R1 can also be alkoxy; B is phenyl, methylphenyl, chlorophenyl, hydroxyphenyl or the moiety STR2 E is hydrogen, hydroxyl or acetoxy; and C is a center of chirality. These compounds are particularly useful for their antimicrobial and, particularly, antibacterial effects.

Cephalosporins and their production

Cephalosporins of the formula STR1 their pharmaceutically-acceptable, nontoxic salts, and hydrates thereof are produced, wherein A is hydrogen; unsubstituted or substituted alkyl; aryl; or R1 --X--, wherein X is --CO-- or --SO2 --, and R1 is hydrogen, unsubstituted or substituted alkyl; aryl; thienyl; furyl; amino; alkylamino; dialkylamino; pyrrolidyl; or piperidyl; Or when X is --CO--, R1 can also be alkoxy; B is phenyl, methylphenyl, chlorophenyl, hydroxyphenyl or the moiety STR2 E is hydrogen, hydroxyl or acetoxy; and C is a center of chirality. These compounds are particularly useful for their antimicrobial and, particularly, antibacterial effects.