62868-39-7

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-METHOXYPHENYL)TETRAHYDRO-2H-IMIDAZOL-2-ONE is used as a potential drug candidate for the development of new medications. Its application is driven by the compound's potential biological activity, which is currently under investigation for therapeutic effects.
Used in Neurological Disorders Treatment:
In the field of neurology, 1-(4-METHOXYPHENYL)TETRAHYDRO-2H-IMIDAZOL-2-ONE is studied for its potential role in the treatment of neurological disorders. The exact mechanism of its action in this context is still under research, but the compound's unique structure suggests it may interact with biological targets relevant to these conditions.
Used as an Analgesic:
1-(4-METHOXYPHENYL)TETRAHYDRO-2H-IMIDAZOL-2-ONE is also being explored for its potential as an analgesic, indicating that it may have properties that could help in the management of pain. The specific uses and efficacy as an analgesic are areas of ongoing study to determine its suitability and mechanism of action in pain relief.
The exact applications and mechanisms of 1-(4-METHOXYPHENYL)TETRAHYDRO-2H-IMIDAZOL-2-ONE may vary depending on the research outcomes and the intended use within the pharmaceutical industry. As the investigation into 1-(4-METHOXYPHENYL)TETRAHYDRO-2H-IMIDAZOL-2-ONE's properties and potential therapeutic effects continues, its uses may be further refined and expanded.

InChI:InChI=1/C10H12N2O2/c1-14-9-4-2-8(3-5-9)12-7-6-11-10(12)13/h2-5H,6-7H2,1H3,(H,11,13)

Upstream product

• 24455-93-4 N-(4-methoxyphenyl)ethane-1,2-diamine 
• 530-62-1 1,1'-carbonyldiimidazole 
• 120-93-4 imidazolidone 
• 696-62-8 para-iodoanisole 
• 5416-93-3 4-Methoxyphenyl isocyanate 
• 104-94-9 4-methoxy-aniline 
• 87919-18-4 1-(2-hydroxyethyl)-3-(4-methoxyphenyl)urea 
• 497-25-6 dimethylenecyclourethane 

Downstream Products

• 2033-35-4 4,5-dihydro-1-(4-methoxyphenyl)-3-methylimidazol-2(1H)-one 
• 62868-37-5 3-(4-methoxy-phenyl)-2-oxo-imidazolidine-1-carbonyl chloride 

Relevant academic research and scientific papers

5-HT RECEPTOR MODULATORS

The invention relates to compounds of formula (I), useful for treating disorders mediated by the 5-hydroxytryptamine (serotonin) receptor IB (5-HT1B), e.g. vascular disorders, cancer and CNS disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.

5-HT RECEPTOR MODULATORS

The invention relates to compounds of formula (I), useful for treating disorders mediated by the 5-hydroxytryptamine (serotonin) receptor 1B (5-HT1B), e.g. vascular disorders, cancer and CNS disorders. The invention also provides methods of treating such disorders, and componnds and compositions etc. for their treatment

Mild, convenient and versatile Cu-mediated synthesis of N-aryl-2-imidazolidinones

A mild, general, convenient and practical methodology for the selective copper-mediated mono N-arylation of unprotected 2-imidazolidinone was developed. Strong electron-donating groups and free hydroxy and amino groups on the aryl iodide substrates were well tolerated. The use of n-butanol as the solvent for the copper-catalysed mono-arylation of 2-imidazolidinone is unprecedented.

Lithiation of 1-arylimidazol-2(1H)-ones and 1-aryl-4,5-dihydroimidazol- 2(1H)-ones

1-Arylimidazol-2(1H)-ones are shown to be readily lithiated, using 2 mol equiv. of n-butyllithium, on the benzene ring, ortho to the heterocycle. 1-Aryl-4,5-dihydroimidazol-2(1H)-ones also undergo metalation on the aromatic substitutuent ortho to the heterocycle, but less efficiently. 1-Aryl-3-methylimidazol-2(1H)-ones are lithiated on the heterocyclic ring and then on the benzene ring ortho to the heterocycle. No ortho-directing effect was found for 1-aryl-4,5-dihydro-3-methylimidazol-2(1H)-ones.

Investigation of the Mitsunobu reaction of N-(2-hydroxyethyl)-N'- phenyl-ureas

The Mitsunobu reaction of N-(2-hydroxyethyl)-ureas 1 using PPh3 and EtO2CN=NCO2Et led to the mixture of N- and O-alkylation products or a single isomer depending on the substrates.