87919-18-4

Usage

Uses

Used in Pharmaceutical Applications:
1-(2-hydroxyethyl)-3-(4-methoxyphenyl)urea is used as a drug intermediate for the development of new pharmaceuticals. Its unique structure allows it to potentially interact with enzymes and receptors in the body, making it a valuable compound for the creation of novel medications.
Used in Research:
1-(2-hydroxyethyl)-3-(4-methoxyphenyl)urea is used as a building block in the synthesis of more complex molecules for research purposes. Its potential interactions with biological targets make it an interesting candidate for further study and development in various scientific fields.
Used in Chemical Synthesis:
1-(2-hydroxyethyl)-3-(4-methoxyphenyl)urea is used as a key component in the synthesis of complex organic molecules. Its versatile structure allows for the creation of a wide range of compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 100-07-2 4-methoxy-benzoyl chloride 
• 3532-17-0 4-methoxybenzoyl azide 
• 20950-96-3 (4-methoxyphenyl)carbamic acid phenyl ester 
• 141-43-5 ethanolamine 
• 104-94-9 4-methoxy-aniline 
• 5416-93-3 4-Methoxyphenyl isocyanate 

Downstream Products

• 1027567-93-6 1-(2-{4-[2,4-Dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxy}-ethyl)-3-(4-methoxy-phenyl)-urea 
• 1848-63-1 (4,5-dihydro-oxazol-2-yl)-(4-methoxy-phenyl)-amine 
• 62868-39-7 1-(4-methoxyphenyl)-2-imidazolidinone 
• 1027724-67-9 1-[2-(4-Formyl-phenoxy)-ethyl]-3-(4-methoxy-phenyl)-urea 

Relevant academic research and scientific papers

Synthesis and evaluation in vitro of 1-[2-(10-dihydroartemisininoxy) ethyl]-3-phenylurea derivatives as potential agents against cancer

In order to develop potent and selective anticancer agents, a series of novel artemisinin derivatives bearing urea moiety 1a-n were facilely synthesized herein and screened for their activities in vitro against ten human tumor cell lines (HeLa, MCF-7, U937, K562, HL60, HCT116, HepG2, A549, A375-S2, and HT1080). The pharmacological results indicated that some compounds showed excellent activity against cancer cell lines and good selectivity, especially the compound 1c which proved to be the most active against the cancer cells as well as distinctive patterns of selectivity.

A convenient method of synthesis of unsymmetrical urea derivatives

A method for the preparation of unsymmetrical urea derivatives that may contain functional groups such as hydroxyl, amine, amide, and carboxyl is described. The method consists of a one-pot modified Curtius rearrangement starting with appropriate aromatic acid chloride and carried out in a nonaqueous system.

Investigation of the Mitsunobu reaction of N-(2-hydroxyethyl)-N'- phenyl-ureas

The Mitsunobu reaction of N-(2-hydroxyethyl)-ureas 1 using PPh3 and EtO2CN=NCO2Et led to the mixture of N- and O-alkylation products or a single isomer depending on the substrates.