628690-03-9

Upstream product

• 20258-50-8 1,2,5,6-tetra-O-benzyl-3,4-O-isopropylidene-D-mannitol 
• 33493-69-5 (1R,1'R)-1,1'-[(4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl]diethane-1,2-diol 
• 100-39-0 benzyl bromide 

Downstream Products

• 20196-70-7 (+)-(R)-2,3-bis(benzyloxy)propanal 

Relevant academic research and scientific papers

A cross-metathesis approach to the stereocontrolled synthesis of the AB ring segment of ciguatoxin

Synthesis of the AB ring segments of ciguatoxin is described. The present synthesis includes a Lewis acid mediated cyclization of allylstannane with aldehyde, cross-metathesis reaction introducing the side chain, and Grieco-Nishizawa dehydration on the A ring.

1,2,5,6-Tetra-O-benzyl-D-mannitol derivatives as novel HIV protease inhibitors

The synthesis and structure-activity relationships of HIV protease inhibitors derived from carbohydrate alditols are discussed. We disclose a new series of 1,2,5,6-tetra-O-alkyl-D-mannitol exhibiting sub-micromolar activity against HIV-protease. This seri