628718-91-2Relevant academic research and scientific papers
Studies on isocyanides and related compounds: A facile synthesis of 1,6-dihydro-6-oxopyrazine-2-carboxylic acid derivatives via Ugi four-component condensation
Faggi, Cristina,Garcia-Valverde, Maria,Marcaccini, Stefano,Pepino, Roberto,Pozo, Ma. Cruz
, p. 1553 - 1558 (2007/10/03)
The Ugi four-component condensation (U-4CC) between arylglyoxals 7, amines 6, benzoylformic acid (4) and isocyanides 5 afforded the expected products 8 which were cyclized in a 5+1 fashion with ammonium acetate to give 1,N-disubstituted 4-aryl-1,6-dihydro-6-oxo-5-phenylpyrazine-2-carboxamides 9 in good yields. Evidence for the assigned structures 9 was provided by 13C NMR spectra and X-ray analysis of 9a.
