62878-59-5

Upstream product

• 2010-06-2 2-Amino-4-phenylthiazole 
• 90-02-8 salicylaldehyde 
• 98-86-2 acetophenone 
• 89-95-2 2-methyl-benzyl alcohol 

Downstream Products

• 67947-77-7 N-[2-(2-hydroxy-phenyl)-4-oxo-1-(4-phenyl-thiazol-2-yl)-azetidin-3-yl]-phthalimide 
• 66385-98-6 2'-(2-hydroxy-phenyl)-4-phenyl-[2,3']bithiazolyl-4'-one 
• 77203-86-2 2-[(2-Hydroxy-phenyl)-(4-phenyl-thiazol-2-ylamino)-methyl]-cyclohexanone 
• 756479-95-5 bis[2-(2-hydroxybenzylideneaminato)-4-phenylthiazolato]zinc(II) monohydrate 

Relevant academic research and scientific papers

2-Hydroxybenzylidene-4-(4-SubstitutedPhenyl)-2-amino Thiazole and their Pt (II) complexes: Synthesis, characterization and biological study

Newly prepared Schiff bases; 2-Hydroxybenzylidene-4-x-phenyl)-2-aminothiazole,where x=H NO2 - CH3, -OCH3, –F, and -Cl (L1-L6), and their corresponding Pt (II) complexes (Pt(L1)s

Characterization of synthesized phenylthiazoly-liminomethyls and some metal-complex derivatives irradiated with γ-rays

TWO SCHIFF-BASES I and II were prepared by the condensation reaction between the amine-2-amino-4-phenylthiazole and the aldehydes salicylaldehyde and o-phthalaldehydic acid-respectively in 1:1 molar ratio. The metal-complex derivatives of Fe3+, Co2+, Ni2+, Cu2+, Zn 2+ and La3+ were also prepared for each ligand. The elemental analysis,IR,UV-Visible,1H NMR and MS spectral analyses served the structure elucidation. The products were γ-irradiated and the post-radiation UV-Visible results were studied. Some radiolysis products were suggested with the assistance,of the obtained MS results. The TGA events described the thermal stability and coordination establishment of the metal derivatives. In association with the UV-Visible data and magnetic behavior of metal- complexes,the octahedral geometry was suggested for most of the investigated products. However, Cu-complexes revealed distorted arrangement. Most of the derivatives exhibited low molar conductance values illustrating the association of amines in the coordination sphere and the non-electrolyte behavior. The antimicrobial activity tests showed significant inhibition against the Gram-positive Bacillus subtilis (NCTC-1040) by the Cu-complexes. Nevertheless, only the Cu-complexes of II displayed similarly against Streptococcus pyogens (ATCC-19615). The Co- complex of II revealed also significant inhibition against the Gram-negative E.coli as well as against the fungus Aspergillus fungatus .

Synthesis of Schiff bases and oxazolidines from 2-amino-4-phenylthiazole

Reactions of 2-amino-4-phenylthiazole with aromatic aldehydes gave the corresponding Schiff bases which were reduced with sodium tetrahydridoborate to amines. Reactions of the Schiff bases with 2-methyloxirane, 2- chloromethyloxirane, and 2-phenoxymethylo

Synthesis and antioxidant activity of 2-amino-4-phenyl-1,3-thiazole derivatives

Azomethines and their hydrogenated derivatives were synthesized in the reaction of 2-amino-4-phenyl-1,3-thiazole with various hydroxyl-containing aldehydes. The synthesized compounds exhibit high antioxidant activity in the inhibited oxidation of cumene.

Synthesis and characterization of PbII, SnII, Hg II and ZnII complexes with Schiff base of aminothiazoles

Some new complexes of HgII, SnII, PbII and ZnII of the type [M(X)2(L)] (where X = Cl, Br and L = Schiff base ligand of aminothiazoles) have been synthesised and characterized by physicochcmical methods.

Some transformations of 2-amino-4-phenyl-1,3-thiazole

Reactions of 2-amino-4-phenyl-1,3-thiazole with aromatic aldehydes, phenyl isocyanate, and carboxylic acid chlorides were studied.

Synthesis and complexing properties of 4-arylthiazolyl-substituted Schiff bases

Reactions of 2-amino-4-arylthiazoles with aromatic aldehydes afforded the corresponding Schiff bases. Complex formation of the latter with nickel, zinc, cobalt, manganese, and copper salts was studied.

Synthesis and Biological Activity of Some Schiff Bases Derived from Thiazoles and Benzothiazoles

4-Aryl-2-aminothiazoles and 2-aminobenzothiazoles undergo condensation with salicylaldehyde in the presence of piperidine to give the schiff bases II and III, respectively.A similar reaction of 4-aryl-2-aminothiazole methiodides gives the schiff bases 4-aryl-2-(2'-hydroxyaryliminomethyl)thiazole methiodides (IV).Several schiff bases have been condensed with cyclohexanone and thioglycollic acid to furnish 4-aryl-2-(2'-hydroxy-α-substituted benzylamino)thiazoles (V) and 2-(2'-hydroxyphenyl) or naphthyl)-3-(4''-arylthiazol-2''-yl)-4-thiazolidones (VI), respectively.Structure elucidation of the schiff bases has been made on the basis of their elemental analyses, IR and mass spectral data.The biological screening data of the schiff bases and their metal complexes are also presented.

Kinetics of Hydrolysis of N-Salicylidene-2-amino-4-substituted-phenylthiazoles

The kinetics of hydrolysis of schiff bases, N-salicylidene-2-amino-(4-substituted phenyl)thiazoles have been investigated in 20percent ethanol-water at 30.0 +/- 0.5 deg C, pH = 4.05-5.90 and I = 0.05 mol dm-3.The reaction proceeds via uncatalys