62892-26-6Relevant academic research and scientific papers
Gold(I) thiotetrazolates as thioredoxin reductase inhibitors and antiproliferative agents
Serebryanskaya, Tatiyana V.,Lyakhov, Alexander S.,Ivashkevich, Ludmila S.,Schur, Julia,Frias, Corazon,Prokop, Aram,Ott, Ingo
, p. 1161 - 1169 (2015/02/02)
Gold(I) complexes with phosphane and thiotetrazolate ligands were prepared and investigated as a new type of bioactive gold metallodrugs. The complexes triggered very efficient inhibition of the enzyme thioredoxin reductase (TrxR), which is an important molecular target for gold species. Strong cytotoxic effects were observed in MDA-MB-231 breast adenocarcinoma and HT-29 colon carcinoma cells, and the complexes also caused strong effects in vincristine resistant Nalm-6 leukemia cells. Cellular uptake studies showed elevated cellular gold levels for complexes containing a triphenylphosphane ligand, whereas trifurylphosphane analogues accumulated at significantly lower cellular concentrations.
Metallophilic bonding and agostic interactions in gold(I) and silver(I) complexes bearing a thiotetrazole unit
Ilie, Adriana,Rat, Ciprian I.,Scheutzow, Susanne,Kiske, Christiane,Lux, Karin,Klapoetke, Thomas M.,Silvestru, Cristian,Karaghiosoff, Konstantin
, p. 2675 - 2684 (2011/07/07)
Gold(I) and silver(I) complexes of 1-methyl-5-thio-tetrazole (1) have been prepared and the coordination chemistry of this ligand toward metal-phosphine frameworks has been explored. As indicated by IR and Raman data, ligand 1 is deprotonated and the resu
