62893-54-3

Basic information

• Product Name: 2-Cyclopropyl ethylamine (free base)
• Synonyms: 2-Cyclopropyl ethylamine (free base);2-Cyclopropyl ethylamine;2-cyclopropylethylamine, HCl
• CAS NO: 62893-54-3
• Molecular Formula: C₅H₁₁N
• Molecular Weight: 85.15
• Product Categories: Cycloalkanes
• Mol File: 62893-54-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 89.133°C at 760 mmHg
• Flash Point: 1.181°C
• Appearance: /
• Density: 0.901g/cm³
• Vapor Pressure: 59.373mmHg at 25°C
• Refractive Index: 1.477
• CAS DataBase Reference: 2-Cyclopropyl ethylamine (free base)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyclopropyl ethylamine (free base)(62893-54-3)
• EPA Substance Registry System: 2-Cyclopropyl ethylamine (free base)(62893-54-3)

Safety Data

• Hazardous Substances Data: 62893-54-3(Hazardous Substances Data)

Usage

General Description

2-Cyclopropyl ethylamine (free base) is a chemical compound with the molecular formula C5H11N. It is a cyclopropyl derivative of ethylamine, and is primarily used in the preparation and synthesis of various pharmaceutical compounds and organic molecules. The compound is a clear, colorless liquid at room temperature and is soluble in water and most organic solvents. It is also known for its mildly pungent odor. 2-Cyclopropyl ethylamine (free base) is commonly used as a building block in organic chemistry and drug development, and is considered a valuable intermediate in the synthesis of various pharmaceutical compounds. It is important to handle and store this chemical with care as it can be harmful if ingested or inhaled, and may cause irritation to the skin and eyes.

InChI:InChI=1/C5H11N/c6-4-3-5-1-2-5/h5H,1-4,6H2

Upstream product

• 6542-60-5 2-cyclopropylacetonitrile 
• 53432-87-4 ethyl 2-cyclopropyl acetate 
• 89580-05-2 2-cyclopropylacetamide 
• 1360591-19-0 (2-nitroethyl)cyclopropane 
• 54120-03-5 1-(cyclopropyl)-2-nitroethanol 

Downstream Products

• 881189-17-9 N-(2-cyclopropylethyl)-4-[4-(5-fluoro-2-trifluoromethylbenzoyl)piperazin-1-yl]benzamide 
• 840488-85-9 6-chloropyridazine-3-carboxylic acid (2-cyclopropylethyl)amide 

Relevant articles and documents

New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-Butyl-2,3- dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: Variations at the 5 position

We report an expansion of the scope of our initial discovery that 5- keto-substituted 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofurans (DHDMBFs) are antiinflammatory and analgesic agents. Several other functional groups have been introduced at the 5 position: amides, amidines, ureas, guanidines, amines, heterocycles, heteroaromatics, and heteroaryl ethenyl substituents in the 5 position all provide active compounds. These compounds are dual cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) inhibitors. They inhibit both COX-1 and COX-2 with up to 33-fold selectivity for COX-2.

2-process for the preparation of cyclopropyl-ethylamine

The invention discloses a preparation method of 2-cyclopropyl ethylamine. The method includes the steps of A, compound 1 and nitromethane react under the action of alkali to obtain compound 2; B, the compound 2 is dehydrated under the action of dehydration reagent to obtain compound 3; C, the compound 3 reacts in solvent under the action of reducing agent to obtain compound 4; D, the compound 4 reacts under the action of reduction hydrogenation catalyst to obtain compound 5, namely the 2-cyclopropyl ethylamine. The preparation method has the advantages that operation conditions can be simplified, cost can be lowered, and easiness in large batch production is achieved. The synthesizing route is showed as follows.

NOVEL COMPOUNDS

The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, X, m, R2, Y, R3, Z, n, R4, A and B are as defined in the specification, processes for their prep