629-96-9

Usage

Uses

Used in Skin Care Industry:
1-Eicosanol is used as an emollient for its moisturizing properties, helping to maintain skin hydration and suppleness.
Used in Chemical Production:
1-Eicosanol is used as an intermediate in the production of fatty amine derivatives, lubricant additives, and surfactants, contributing to the formulation of various industrial and consumer products.
Used in Pharmaceutical and Agrochemical Industries:
1-Eicosanol is studied for its potential anti-inflammatory properties, which could be utilized in the development of pharmaceuticals for treating inflammation-related conditions. Additionally, its insecticidal properties are of interest for the agrochemical industry, potentially leading to the development of new pest control agents.

InChI:InChI=1/C20H42O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21/h21H,2-20H2,1H3

Upstream product

• 75-21-8 oxirane 
• 92206-73-0 1-octadecylmagnesium bromide 
• 506-30-9 Arachidic acid 
• 18281-05-5 ethyl eicosanoate 
• 1120-28-1 methyl arachidate 
• 137324-72-2 2-Octadecylidene-dithiomalonic acid di-S-ethyl ester 
• 4861-61-4 2-dodecylthiophene 
• 112-95-8 icosane 
• 629-97-0 n-docosane 
• 630-01-3 n-hexacosane 
• 593-45-3 octadecane 
• 646-31-1 tetracosane 
• 630-02-4 octacosane 
• 638-68-6 n-triacontane 

Downstream Products

• 872515-97-4 mono-eicosyl ortho-phthalate 
• 34994-81-5 1-iodoeicosane 
• 4276-49-7 1-Bromoeicosane 
• 506-30-9 Arachidic acid 
• 822-24-2 eicosyl acetate 
• 52991-96-5 eicosyl-vinyl ether 
• 53954-12-4 p-Benzophenoncarbonsaeureeikosylester 
• 3381-25-7 methanesulfonic acid icosyl ester 
• 2400-66-0 icosanal 
• 253680-69-2 2-eicosyloxy-6-hydroxy-benzoic acid methyl ester 
• 397242-84-1 ((2S,3R,4R,5R)-1-Acetyl-3,4-bis-benzyloxy-5-benzyloxymethyl-pyrrolidin-2-ylmethyl)-phosphonic acid monoicosyl ester 
• 543691-26-5 ((3S,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-ylmethyl)-phosphonic acid monoicosyl ester 
• 948827-69-8 (E)-3-(4-Benzyloxy-phenyl)-acrylic acid icosyl ester 
• 357914-22-8 (E)-3-(3,4-Bis-benzyloxy-phenyl)-acrylic acid icosyl ester 

Relevant academic research and scientific papers

MOF-derived hcp-Co nanoparticles encapsulated in ultrathin graphene for carboxylic acids hydrogenation to alcohols

Highly efficient conversion of carboxylic acids to valuable alcohols is a great challenge for easily corroded non-noble metal catalysts. Here, a series of few-layer graphene encapsulated metastable hexagonal closed-packed (hcp) Co nanoparticles were fabricated by reductive pyrolysis of metal-organic framework precursor. The sample pyrolyzed at 400 °C (hcp-Co@G400) presented outstanding performance and stability for converting a variety of functional carboxylic acids and its turnover frequency was one magnitude higher than that of conventional facc-centered cubic (fcc) Co catalysts. In situ DRIFTS spectroscopy of model reaction acetic acid hydrogenation and DFT calculation results confirm that carboxylic acid initially undergoes dehydroxylation to RCH2CO* followed by consecutive hydrogenation to RCH2CH2OH through RCH2COH*. Acetic acid prefers to vertically adsorb at hcp-Co (0 0 2) facet with a much lower adsorption energy than parallel adsorption at fcc-Co (1 1 1) surface, which plays a key role in decreasing the activation barrier of the rate-determining step of acetic acid dehydroxylation.

Discovery of Anti-TNBC Agents Targeting PTP1B: Total Synthesis, Structure-Activity Relationship, in Vitro and in Vivo Investigations of Jamunones

Twenty-three natural jamunone analogues along with a series of jamunone-based derivatives were synthesized and evaluated for their inhibitory effects against breast cancer (BC) MDA-MB-231 and MCF-7 cells. The preliminary structure-activity relationship revealed that the length of aliphatic side chain and free phenolic hydroxyl group at the scaffold played a vital role in anti-BC activities and the methyl group on chromanone affected the selectivity of molecules against MDA-MB-231 and MCF-7 cells. Among them, jamunone M (JM) was screened as the most effective anti-triple-negative breast cancer (anti-TNBC) candidate with a high selectivity against BC cells over normal human cells. Mechanistic investigations indicated that JM could induce mitochondria-mediated apoptosis and cause G0/G1 phase arrest in BC cells. Furthermore, JM significantly restrained tumor growth in MDA-MB-231 xenograft mice without apparent toxicity. Interestingly, JM could downregulate phosphatidylinositide 3-kinase (PI3K)/Akt pathway by suppressing protein-tyrosine phosphatase 1B (PTP1B) expression. These findings revealed the potential of JM as an appealing therapeutic drug candidate for TNBC.

Enantiomeric synthesis of natural alkylglycerols and their antibacterial and antibiofilm activities

Alkylglycerols (AKGs) are bioactive natural compounds that vary by alkyl chain length and degree of unsaturation, and their absolute configuration is 2S. Three AKGs (5l–5n) were synthesised in enantiomerically pure form, and were characterised for the first time together with 12 other known and naturally occurring AKGs (5a–5k, 5o). Their structures were established using 1H and 13C APT NMR with 2D-NMR, ESI-MS or HRESI-MS and optical rotation data, and they were tested for their antibacterial and antibiofilm activities. AKGs 5a–5m and 5o showed activity against five clinical isolates and P. aeruginosa ATCC 15442, with MIC values in the range of 15–125 μg/mL. In addition, at half of the MIC, most of the AKGs reduced S. aureus biofilm formation in the range of 23%–99% and P. aeruginosa ATCC 15442 biofilm formation in the range of 14%–64%. The antibiofilm activity of the AKGs assessed in this work had not previously been studied.

METHOD FOR THE PRODUCTION OF PRIMARY LONG-CHAIN ALCOHOLS

The invention relates to a method for the production of linear long-chain alcohols with 20 to 40 carbon atoms by means of a growth reaction with ethylene on aluminium compounds.

Semivolatile and volatile compounds in combustion of polyethylene

The evolution of semivolatile and volatile compounds in the combustion of polyethylene (PE) was studied at different operating conditions in a horizontal quartz reactor. Four combustion runs at 500 and 850°C with two different sample mass/air flow ratios and two pyrolytic runs at the same temperatures were carried out. Thermal behavior of different compounds was analyzed and the data obtained were compared with those of literature. It was observed that α,ω-olefins, α-olefins and n-paraffins were formed from the pyrolytic decomposition at low temperatures. On the other hand, oxygenated compounds such as aldehydes were also formed in the presence of oxygen. High yields were obtained of carbon oxides and light hydrocarbons, too. At high temperatures, the formation of polycyclic aromatic hydrocarbons (PAHs) took place. These compounds are harmful and their presence in the combustion processes is related with the evolution of pyrolytic puffs inside the combustion chamber with a poor mixture of semivolatile compounds evolved with oxygen. Altogether, the yields of more than 200 compounds were determined. The collection of the semivolatile compounds was carried out with XAD-2 adsorbent and were analyzed by GC-MS, whereas volatile compounds and gases were collected in a Tedlar bag and analyzed by GC with thermal conductivity and flame ionization detectors.

Thiol esters in organic synthesis XVII. S,S'-diethyl dithiomalonate as masked ethanol carbanion and 1,3-diol equivalent in the Knoevenagel condensation

S,S'-Diethyl dithiomalonate (1) has been shown to be a useful reagent in the Knoevenagel condensation with aldehydes, using DABCO as the base. The resultant products can be reduced either to 1,3-diols by use of sodium borohydride or to ethanol derivatives using Raney Nickel.

A New Synthesis of Long Chain Acid Esters and Carbinols

A versatile synthesis of difficulty accessible long chain acid esters and carbinols is described.The synthesis involves acylations at 2- and 5-positions of thiophene.Thioketalation of the resulting ketoesters followed by Raney nickel desulfurization yield acid esters which on LAH reduction give the corresponding carbinols.

Silicate-based surfactant composition

A novel silicate-based surfactant composition is prepared by a selective process involving (1) reaction of silicon tetrahalide with water and alcohol followed by (2) transesterification with a polyether alcohol. The resulting surfactant composition is utilized as a stabilizer in the production of polyurethane foam.