253680-69-2Relevant academic research and scientific papers
6-Oxa isosteres of anacardic acids as potent inhibitors of bacterial histidine protein kinase (HPK)-mediated two-component regulatory systems
Kanojia, Ramesh M.,Murray, William,Bernstein, Jeffrey,Fernandez, Jeffrey,Foleno, Barbara D.,Krause, Heather,Lawrence, Laura,Webb, Glenda,Barrett, John F.
, p. 2947 - 2952 (2007/10/03)
A series of 6-oxa isosteres of anacardic acids (6-higher alkyl/alkenyl-2-hydroxybenzoic acids) was synthesised and several members were discovered to be among the most potent inhibitors (IC50 values ≤ 5 μM) of the bacterial two-component regulatory systems, KinA/SpoOF and NRII/NRI, reported to date. The Gram-positive antibacterial activity in selected strains is also presented.
