62906-30-3Relevant academic research and scientific papers
Diguanidinocalix[4]arenes as effective and selective catalysts of the cleavage of diribonucleoside monophosphates
Salvio, Riccardo,Cacciapaglia, Roberta,Mandolini, Luigi,Sansone, Francesco,Casnati, Alessandro
, p. 34412 - 34416 (2014)
Calix[4]arenes derivatives 1 and 2, featuring two guanidine units at the upper rim, catalyze the transesterification of diribonucleoside monophosphates much more effectively than that of HPNP. Rate accelerations relative to the background range from 10su
Chiral Nanozymes-Gold Nanoparticle-Based Transphosphorylation Catalysts Capable of Enantiomeric Discrimination
Chen, Jack L.-Y.,Pezzato, Cristian,Scrimin, Paolo,Prins, Leonard J.
supporting information, p. 7028 - 7032 (2016/05/19)
Enantioselectivity in RNA cleavage by a synthetic metalloenzyme has been demonstrated for the first time. Thiols containing chiral ZnII-binding head groups have been self-assembled on the surface of gold nanoparticles. This results in the spontaneous formation of chiral bimetallic catalytic sites that display different activities (kcat) towards the enantiomers of an RNA model substrate. Substrate selectivity is observed when the nanozyme is applied to the cleavage of the dinucleotides UpU, GpG, ApA, and CpC, and remarkable differences in reactivity are observed for the cleavage of the enantiomerically pure dinucleotide UpU.
Interconversion and Phosphoester Hydrolysis of 2',5'- and 3',5'-Dinucleoside Monophosphates: Kinetics and Mechanisms
Jaervinen, Pia,Oivanen, Mikko,Loennberg, Harri
, p. 5396 - 5401 (2007/10/02)
First-order rate constants for the interconversion and hydrolytic cleavage of several 2',5'- and 3',5'-dinucleoside monophosphates (UpU, UpA, ApU, ApA) have been determined over an acidity range from H0 = -0.2 to H- = 12.4 at 363.2 K.Both reactions proceed at comparable rates at pH a of the phosphate moiety (0.7) and second-order under less acidic conditions (pH 1-2).With dinucleoside monophosphates derived from adenosine, acid-catalyzed depurination of the starting material competes with the phosphate migration and phosphoester hydrolysis at pH 4.Under these conditions the migration is considerably faster than the phosphoester hydrolysis, which exhibits acid catalysis at pH 8).The reaction is first order with respect to hydroxide ion at -> -3 and approaches zero-order dependence at higher alkalinities, where the unesterified 2'- or 3'-hydroxyl group becomes ionized.The mechanisms of different partial reactions, and the effects of base moiety structure (purine vs pyrimidine) on their rates are discussed.The data are compared to the known reaction kinetics of monoalkyl esters of adenosine 2'- and 3'-monophosphates.
