62909-66-4

Usage

Uses

Used in Pharmaceutical Industry:
4-Amino-3,5-dichlorobenzaldehyde is used as a reagent for the synthesis of pyrazolopyridine derivatives, which serve as inhibitors of phosphodiesterase-4 (PDE-IV). These inhibitors play a crucial role in modulating the inflammatory response and are being investigated for their potential therapeutic applications in treating various diseases, including chronic obstructive pulmonary disease (COPD) and asthma.
Additionally, 4-Amino-3,5-dichlorobenzaldehyde is utilized in the production of tumor necrosis factor-α (TNF-α), a cytokine involved in systemic inflammation and immune responses. Modulating TNF-α levels can be beneficial in treating autoimmune diseases and certain cancers.
Used in Chemical Synthesis:
4-Amino-3,5-dichlorobenzaldehyde is also employed as a reagent in the synthesis of amino acid derivatives, which act as neuropeptide Y antagonists. These antagonists have potential applications in the treatment of various conditions, such as obesity, anxiety, and depression, by modulating the neuropeptide Y system.
Furthermore, 4-Amino-3,5-dichlorobenzaldehyde is recognized as an impurity in Clenbuterol (C569998, HCl), a medication used for treating asthma and other respiratory conditions. Its presence in the synthesis process highlights the importance of controlling the purity of active pharmaceutical ingredients to ensure the safety and efficacy of the final product.

Upstream product

• 63467-40-3 4-aminobenzaldehyde monohydrochloride 
• 64-19-7 acetic acid 
• 697-89-2 2,6-dichloro-4-iodoaniline 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 

Downstream Products

• 56961-76-3 3,4,5-trichlorobenzaldehyde 
• 634-93-5 2,4,6-trichloroaniline 
• 101183-39-5 4-Amino-3,5-dichloro-styrene 
• 78473-00-4 4-amino-3,5-dichlorobenzonitrile 
• 860563-51-5 3,4,5-trichloro-2,6-dinitro-benzoic acid 
• 860563-47-9 3,4,5-trichloro-2-nitro-benzoic acid 
• 51-39-8 3,4,5-trichlorobenzoic acid 
• 704899-62-7 3,4,5-trichloro-2-nitro-benzaldehyde 
• 6379-46-0 1,2,3-trichloro-4,6-dinitrobenzene 

Relevant academic research and scientific papers

Reductive carbonylation of aryl halides employing a two-chamber reactor: A protocol for the synthesis of aryl aldehydes including 13C- and D-isotope labeling

A protocol has been developed for conducting the palladium-catalyzed reductive carbonylation of aryl iodides and bromides using 9-methylfluorene-9- carbonyl chloride (COgen) as a source of externally delivered carbon monoxide in a sealed two-chamber system (COware), and potassium formate as the in situ hydride source. The method is tolerant to a wide number of functional groups positioned on the aromatic ring, and it can be exploited for the isotope labeling of the aldehyde group. Hence, reductive carbonylations run with 13COgen provide a facile access to 13C-labeled aromatic aldehydes, whereas with DCO2K, the aldehyde is specifically labeled with deuterium. Two examples of double isotopic labeling are also demonstrated. Finally, the method was applied to the specific carbon-13 labeling of the β-amyloid binding compound, florbetaben.

Heteroarylethanol-pyridylalkylamines for controlling animal growth

A compound for promoting livestock production and for controlling obesity in humans and animals, of the formula STR1 in which A represents =CH-- or =N--, R0 represents hydrogen or methyl, R1 and R3 each independently represents hydrogen, hydroxyl, halogen, cyano, alkyl, halogenoalkyl, hydroxyalkyl, alkoxycarbonyl, aminocarbonyl, mono- and dialkylaminocarbonyl, alkoxy, halogenoalkoxy, halogenoalkylthio, NHSO2 -alkyl, R2 represents hydrogen, hydroxyl, alkoxy or the radical --NR5 R6, R4 represents hydrogen, C1 -C10 -alkyl which is optionally substituted by hydroxyl, halogen, alkoxy, acyloxy or the radical --NH7 R8, or represents the radical COR9 or the radical --O--Z--R10, Z represents C1 -C10 -alkylene, -alkenylene or alkynylene, R5 represents hydrogen or alkyl, R6 represents hydrogen, alkyl, halogenoalkyl or acyl, or R5 and R6 together with the adjoining N atom form a saturated or unsaturated heterocyclic 4-, 5- or 6-membered ring, R7 and R8 each independently represents hydrogen, optionally substituted alkyl, optionally substituted aryl, R9 represents hydroxyl, alkoxy or the radical --NR7 R8, R10 represents hydroxyl, alkoxy, acyloxy, optionally substituted aryloxy or aralkyloxy, with the substituent R4 and the alkylamino group in the pyridyl ring of the formula I being in the p position with respect to one another, or a physiologically tolerated salt thereof, or, if A represents nitrogen, optionally the N-oxide thereof.