6292-58-6

Basic information

• Product Name: Benzenesulfonamide, 2,5-dimethyl- (9CI)
• Synonyms: Benzenesulfonamide, 2,5-dimethyl- (9CI);2,5-dimethylbenzenesulfphonamide;BenzenesulfonaMide,2,5-diMethyl-;2,5-XYLENESULFONAMIDE
• CAS NO: 6292-58-6
• Molecular Formula: C₈H₁₁NO₂S
• Molecular Weight: 185.24344
• Product Categories: SULFONAMIDE
• Mol File: 6292-58-6.mol

Chemical Properties

• Melting Point: 145.5-146 °C
• Boiling Point: 349.4°C at 760 mmHg
• Flash Point: 165.1°C
• Appearance: /
• Density: 1.227g/cm³
• Vapor Pressure: 4.72E-05mmHg at 25°C
• Refractive Index: 1.554
• PKA: 10.26±0.60(Predicted)
• CAS DataBase Reference: Benzenesulfonamide, 2,5-dimethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, 2,5-dimethyl- (9CI)(6292-58-6)
• EPA Substance Registry System: Benzenesulfonamide, 2,5-dimethyl- (9CI)(6292-58-6)

Safety Data

• Hazardous Substances Data: 6292-58-6(Hazardous Substances Data)

Usage

Uses

Used in Research Applications:
Benzenesulfonamide, 2,5-dimethyl(9CI) is utilized as a research chemical for exploring its unique structural features and potential applications in synthetic and medicinal chemistry. Its distinct properties, conferred by the methyl groups on the benzene ring, make it a valuable compound for studying the effects of structural modifications on chemical behavior and reactivity.
Used in Pharmaceutical Development:
While not currently a mainstay in the pharmaceutical industry, the compound's structural characteristics may inspire the development of new drugs. Its use in this context is as a starting material or a building block in the synthesis of novel pharmaceutical agents, potentially leading to the discovery of new treatments or therapeutic approaches.
Used in Chemical Synthesis:
In the field of chemical synthesis, Benzenesulfonamide, 2,5-dimethyl(9CI) serves as an intermediate or a reactant in the preparation of more complex organic molecules. Its unique structure can be leveraged to create a variety of chemical products, contributing to the advancement of organic chemistry and its applications.

InChI:InChI=1/C8H11NO2S/c1-6-3-4-7(2)8(5-6)12(9,10)11/h3-5H,1-2H3,(H2,9,10,11)

Upstream product

• 19925-28-1 N-Ethyl-2,5-dimethyl-benzenesulfonamide 
• 609-54-1 2,5-dimethylbenzenesulfonic acid 
• 19040-62-1 2,5-dimethylbenzenesulfonyl chloride 

Downstream Products

• 14068-00-9 2,5.Dimethyl-benzolsulfonsaeure-benzoylamid 
• 438003-21-5 3-(2,4-dichlorobenzyl)-5-(2,5-dimethylbenzene)sulfonylcarbamoyl-2-methylindole 
• 90779-46-7 3-oxo-2,3-dihydrobenzo[d]isothiazole-6-carboxylic acid 1,1-dioxide 
• 80998-66-9 2-sulfamoylterephthalic acid 
• 80998-67-0 1,4-dimethyl 2-sulfamoylbenzene-1,4-dicarboxylate 
• 1254305-93-5 C₁₇H₁₃ClF₃N₃O₃S 
• 128577-42-4 2-Cyclopentyl-N-{1-[4-(2,5-dimethyl-benzenesulfonylaminocarbonyl)-2-methoxy-benzyl]-1H-indol-6-yl}-acetamide 

Relevant articles and documents

Preparation method and medical application of benzisothiazole and benzothiophene

The invention discloses a preparation method and medical application of benzisothiazole and benzothiophene, and telates to the field of pharmaceutical chemistry. According to the invention, benzisothiazole and benzothiophene are the first type of HIF-2 agonists; compared with a compound M1001 found by the applicant in the earlier stage, the invention has better HIF-2 agonist activity, and has remarkable enhancement activity on expression of mRNA and protein of EPO, VGEF, Glut1, NDRG1 and the like at the downstream of HIF-2, so that the invention can be used for preparing drugs for treating and/or preventing chronic kidney diseases/chronic renal anemia, dyslipidemia and high cholesterol caused by abnormal expression of HIF-2; and the method has a good industrialization prospect.

Multiprotein Dynamic Combinatorial Chemistry: A Strategy for the Simultaneous Discovery of Subfamily-Selective Inhibitors for Nucleic Acid Demethylases FTO and ALKBH3

Dynamic combinatorial chemistry (DCC) is a powerful supramolecular approach for discovering ligands for biomolecules. To date, most, if not all, biologically templated DCC systems employ only a single biomolecule to direct the self-assembly process. To expand the scope of DCC, herein, a novel multiprotein DCC strategy has been developed that combines the discriminatory power of a zwitterionic “thermal tag” with the sensitivity of differential scanning fluorimetry. This strategy is highly sensitive and could differentiate the binding of ligands to structurally similar subfamily members. Through this strategy, it was possible to simultaneously identify subfamily-selective probes against two clinically important epigenetic enzymes: FTO (7; IC50=2.6 μm) and ALKBH3 (8; IC50=3.7 μm). To date, this is the first report of a subfamily-selective ALKBH3 inhibitor. The developed strategy could, in principle, be adapted to a broad range of proteins; thus it is of broad scientific interest.

PROCESS FOR PREPARING 1,1,3-TRIOXO-1,2-BENZOTHIAZOLE-6-CARBOXAMIDE

A process for preparing, 1,1,3-trioxo-1,2-benzothiazole-6-carboxamide of formula (I) comprising: (a) oxidizing 2,5-dimethyl-benzenesulfonamide of formula (II) in the presence of an oxidizing agent to receive 2-sulfamoyl-terephthalic acid of formula (III);

Oxidatively sonochemical dealkylation of various N-alkylsulfonamides to free sulfonamides and aldehydes

Various N-alkylsulfonamides were easily dealkylated to give the corresponding free sulfonamides in moderate to good yields in the presence of (diacetoxyiodo)benzene and iodine under ultrasonic irradiation. Application of this methodology to various N-prot

Novel sonochemical dealkylation of N-alkylsulfonamides in the presence of (diacetoxyiodo)benzene and iodine

Various N-alkylsulfonamides were easily dealkylated in moderate to good yields by the ultrasonic irradiation in the presence of (diacetoxyiodo)benzene and iodine.