6292-58-6

Basic information

• Product Name: Benzenesulfonamide, 2,5-dimethyl- (9CI)
• Synonyms: Benzenesulfonamide, 2,5-dimethyl- (9CI);2,5-dimethylbenzenesulfphonamide;BenzenesulfonaMide,2,5-diMethyl-;2,5-XYLENESULFONAMIDE
• CAS NO: 6292-58-6
• Molecular Formula: C₈H₁₁NO₂S
• Molecular Weight: 185.24344
• Product Categories: SULFONAMIDE
• Mol File: 6292-58-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 145.5-146 °C
• Boiling Point: 349.4°C at 760 mmHg
• Flash Point: 165.1°C
• Appearance: /
• Density: 1.227g/cm³
• Vapor Pressure: 4.72E-05mmHg at 25°C
• Refractive Index: 1.554
• PKA: 10.26±0.60(Predicted)
• CAS DataBase Reference: Benzenesulfonamide, 2,5-dimethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, 2,5-dimethyl- (9CI)(6292-58-6)
• EPA Substance Registry System: Benzenesulfonamide, 2,5-dimethyl- (9CI)(6292-58-6)

Safety Data

• Hazardous Substances Data: 6292-58-6(Hazardous Substances Data)

Usage

General Description

Benzenesulfonamide, 2,5-dimethyl- (9CI) is an organic compound with the chemical formula C8H11NO2S. It is a sulfonamide derivative, which is a class of compounds commonly used as antibiotics and diuretics. This specific compound has two methyl groups attached to the benzene ring, giving it unique chemical properties. Benzenesulfonamide, 2,5-dimethyl- (9CI) is not widely studied or used in industrial or pharmaceutical applications, but its structural features may make it useful for synthetic chemistry or medicinal chemistry research. It is important to handle and store this compound with proper safety precautions, as with any organic chemical.

InChI:InChI=1/C8H11NO2S/c1-6-3-4-7(2)8(5-6)12(9,10)11/h3-5H,1-2H3,(H2,9,10,11)

Upstream product

• 19040-62-1 2,5-dimethylbenzenesulfonyl chloride 
• 609-54-1 2,5-dimethylbenzenesulfonic acid 
• 19925-28-1 N-Ethyl-2,5-dimethyl-benzenesulfonamide 

Downstream Products

• 90779-46-7 3-oxo-2,3-dihydrobenzo[d]isothiazole-6-carboxylic acid 1,1-dioxide 
• 80998-66-9 2-sulfamoylterephthalic acid 
• 80998-67-0 1,4-dimethyl 2-sulfamoylbenzene-1,4-dicarboxylate 
• 1254305-93-5 C₁₇H₁₃ClF₃N₃O₃S 
• 438003-21-5 3-(2,4-dichlorobenzyl)-5-(2,5-dimethylbenzene)sulfonylcarbamoyl-2-methylindole 
• 14068-00-9 2,5.Dimethyl-benzolsulfonsaeure-benzoylamid 
• 128577-42-4 2-Cyclopentyl-N-{1-[4-(2,5-dimethyl-benzenesulfonylaminocarbonyl)-2-methoxy-benzyl]-1H-indol-6-yl}-acetamide 

Relevant articles and documents

Preparation method and medical application of benzisothiazole and benzothiophene

The invention discloses a preparation method and medical application of benzisothiazole and benzothiophene, and telates to the field of pharmaceutical chemistry. According to the invention, benzisothiazole and benzothiophene are the first type of HIF-2 agonists; compared with a compound M1001 found by the applicant in the earlier stage, the invention has better HIF-2 agonist activity, and has remarkable enhancement activity on expression of mRNA and protein of EPO, VGEF, Glut1, NDRG1 and the like at the downstream of HIF-2, so that the invention can be used for preparing drugs for treating and/or preventing chronic kidney diseases/chronic renal anemia, dyslipidemia and high cholesterol caused by abnormal expression of HIF-2; and the method has a good industrialization prospect.

PROCESS FOR PREPARING 1,1,3-TRIOXO-1,2-BENZOTHIAZOLE-6-CARBOXAMIDE

A process for preparing, 1,1,3-trioxo-1,2-benzothiazole-6-carboxamide of formula (I) comprising: (a) oxidizing 2,5-dimethyl-benzenesulfonamide of formula (II) in the presence of an oxidizing agent to receive 2-sulfamoyl-terephthalic acid of formula (III);

Novel sonochemical dealkylation of N-alkylsulfonamides in the presence of (diacetoxyiodo)benzene and iodine

Various N-alkylsulfonamides were easily dealkylated in moderate to good yields by the ultrasonic irradiation in the presence of (diacetoxyiodo)benzene and iodine.