62924-20-3Relevant academic research and scientific papers
A convenient cross-metathesis approach to trisporins
López-Sánchez, Cristóbal,Hernández-Cervantes, Carmen,Rosales, Antonio,álvarez-Corral, Míriam,Mu?oz-Dorado, Manuel,Rodríguez-García, Ignacio
experimental part, p. 9542 - 9549 (2010/02/27)
Three series of trisporins have been prepared using a strategy in which a cross-metathesis is the key step. This reaction has proved to be highly regioselective, allowing the combination of α- or β-ionone derivatives having a 1,1-disustituted olefin with
Dihydroretinoic acids and their derivatives. Synthesis and biological activity
Pawson,Cheung,Han,Trown,Buck,Hansen,Bollag,Ineichen,Pleil,Rueegg
, p. 918 - 925 (2007/10/12)
The syntheses of the ring and four side-chain dihydroretinoic acids and/or their esters, 3-7, are described. The syntheses of several other retinoids containing a substituted aromatic ring are also included. The biological activity of the compounds was evaluated in vivo in a chemically induced mouse skin papilloma test and in vitro in two vitamin A deficient assays. The activity observed for 1a, 1c, and 2a in the former test was partially retained in the dihydro derivatives 4b, 4c, and 6b. Similar results were found in the in vitro assays.
