6293-20-5

Basic information

• Product Name: ETHYL UREIDOACETATE
• Synonyms: ETHYL UREIDOACETATE;ETHYL HYDANTOATE;ETHYL 2-[(AMINOCARBONYL)AMINO]ACETATE;BUTTPARK 45\07-58
• CAS NO: 6293-20-5
• Molecular Formula: C₅H₁₀N₂O₃
• Molecular Weight: 146.14
• Mol File: 6293-20-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 146-148°
• Appearance: /
• CAS DataBase Reference: ETHYL UREIDOACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL UREIDOACETATE(6293-20-5)
• EPA Substance Registry System: ETHYL UREIDOACETATE(6293-20-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 6293-20-5(Hazardous Substances Data)

Usage

Uses

Hydantoic Acid Ethyl Ester is useful for the preparation of benzoylhydantoic acids by reaction with benzoic acids.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 2880, 1950 DOI: 10.1021/ja01163a019

Upstream product

• 623-33-6 glycine ethyl ester hydrochloride 
• 57-13-6 urea 
• 18873-00-2 N-(Phenylhydrazinocarbonyl)-glycinethylester 
• 2949-22-6 Glycine ethyl ester isocyanate 
• 590-28-3 potassium cyanate 
• 459-73-4 GlyOEt*HCl 
• 556-89-8 nitrourea 
• 64-17-5 ethanol 
• 462-60-2 N-carbamoylglycine 

Downstream Products

• 187160-64-1 ethyl 5-hydroxy-3-(3-nitrobenzyl)-2,4-dioxoimidazolidine-1-acetate 
• 7684-19-7 N-[(phenylamino)carbonyl]glycine ethyl ester 
• 859967-38-7 5-(N-phenyl-glycyl)-hydantoic acid ethyl ester 
• 303986-62-1 [3-(4-Nitro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-acetic acid ethyl ester 
• 1027543-34-5 ethyl 3-(2-nitrobenzyl)-2,4,5-trioxoimidazolidine-1-acetate 
• 462-60-2 N-carbamoylglycine 
• 67792-85-2 3-nitroso-hydantoic acid ethyl ester 
• 461-72-3 2,4-imidazolidinedione 
• 98629-84-6 N-ethoxycarbonylmethylbarbituric acid 
• 89694-35-9 ethyl 2,4,5-trioxoimidazolidine-1-acetate 
• 43077-49-2 ethyl [3-(1-diphenoxyphosphinylbutyl)ureido]acetate 
• 96955-15-6 1,3-Bis-(N-ureidoacetyl-aminomethyl)-benzol 
• 95494-01-2 (4-amino-6-anilino-[1,3,5]triazin-2-ylmethyl)-urea 
• 614-22-2 1-benzoylurea 

Relevant articles and documents

Highly selective aldose reductase inhibitors. 1. 3-(Arylalkyl)-2,4,5- trioxoimidazolidine-1-acetic acids

A series of 3-(arylalkyl)-2,4,5-trioxoimidazolidine-1-acetic acids (1) was prepared and tested for aldose reductase (AR) and aldehyde reductase (ALR) inhibitory activities. These compounds showed strong inhibitory activity against AR without significant inhibitory activity for ALR. The ratio of IC50(ALR)IC50(AR) was > 1000 in some compounds. On the basis of pharmacological tests such as the recovery of reduced motor nerve conduction velocity and toxicological profile, 3-(3-nitrobenzyl)-2,4,5- trioxoimidazolidine-1-acetic acid (NZ-314) was selected as the candidate for clinical development.

Description of the preparation of hydantoin and 2-thiohydantoin

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