98629-84-6Relevant academic research and scientific papers
ALKYLATION OF 6-METHOXYURACIL AND A NEW METHOD FOR THE SYNTHESIS OF N-SUBSTITUTED BARBITURIC ACIDS
Krasnov, K. A.,Slesarev, V. I.,Selimanova, I. N.
, p. 1215 - 1220 (2007/10/02)
The alkylation of the metallic salts of 6-methoxyuracil by dimethyl sulfate and alkyl halides leads to the selective formation of 1-alkyl-6-methoxyuracils.The alkylation of these compounds leads to the formation of 1,3-substituted derivatives of 6-methoxyuracil.The acid hydrolysis of 6-methoxyuracils makes it possible to obtain 1- and 1,3-substituted barbituric acids.
Synthesis of Water Soluble 8-Substituted 5-Deazaflavins
Link, P. A. J.,Plas, H. C. van der,Mueller, F.
, p. 873 - 878 (2007/10/02)
By oxidative cyclization of 5,5'-arylmethylenebis(6-methylaminouracil) derivatives with diethyl azodicarboxylate a number of 5-deazaisoalloxazines were synthesized having at the C(8) position a substituent that causes a bathochromic shift varying between 20 and 130 nm, depending on the substituent.To increase the solubility in aqueous media 8-substituted 5-deazaflavins were prepared having a carboxymethyl group at the N(3) position.The carboxymethyl group was introduced prior to the oxidative cyclization.
