6296-06-6 Usage
Uses
Used in Pharmaceutical Applications:
1-(2-hydroxyphenyl)-3-(quinolin-2-yl)propane-1,3-dione is used as a therapeutic agent for its anti-inflammatory properties, which can help alleviate symptoms of conditions such as arthritis and other inflammatory diseases. Its anti-cancer properties make it a promising candidate for the treatment of various types of cancer, including liver, breast, lung, pancreatic, colorectal, and ovarian cancers. Curcumin's antioxidant properties also contribute to its potential in preventing and treating cardiovascular diseases.
Used in Neurodegenerative Disease Treatment:
In the field of neurology, 1-(2-hydroxyphenyl)-3-(quinolin-2-yl)propane-1,3-dione is used as a neuroprotective agent for its potential to treat neurodegenerative diseases such as Alzheimer's. Its ability to modulate various signaling pathways and exhibit synergistic effects with conventional drugs enhances its therapeutic potential in this area.
Used in the Food Industry:
Curcumin, or 1-(2-hydroxyphenyl)-3-(quinolin-2-yl)propane-1,3-dione, is used as a natural coloring agent in the food industry due to its bright yellow hue. It is commonly found in curries and other dishes that utilize turmeric as a spice, adding both color and flavor to the culinary creations.
Used in Cosmetics:
In the cosmetics industry, 1-(2-hydroxyphenyl)-3-(quinolin-2-yl)propane-1,3-dione is used as an ingredient in various skincare and beauty products for its anti-inflammatory and antioxidant properties. These benefits can help improve skin health, reduce inflammation, and protect the skin from environmental damage.
Used in Drug Delivery Systems:
Similar to gallotannin, curcumin's limitations can be overcome by developing novel drug delivery systems. These systems, which may include organic and metallic nanoparticles, aim to enhance curcumin's delivery, bioavailability, and therapeutic outcomes, making it a more effective treatment option for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 6296-06-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,2,9 and 6 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 6296-06:
(6*6)+(5*2)+(4*9)+(3*6)+(2*0)+(1*6)=106
106 % 10 = 6
So 6296-06-6 is a valid CAS Registry Number.
6296-06-6Relevant academic research and scientific papers
Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4
Charvin, Delphine,Pomel, Vincent,Ortiz, Millan,Frauli, Mélanie,Scheffler, Sophie,Steinberg, Edith,Baron, Luc,Deshons, Laurène,Rudigier, Rachel,Thiarc, Delphine,Morice, Christophe,Manteau, Baptiste,Mayer, Stanislas,Graham, Danielle,Giethlen, Bruno,Brugger, Nadia,Hédou, Ga?l,Conquet, Fran?ois,Schann, Stephan
supporting information, p. 8515 - 8537 (2017/11/03)
The metabotropic glutamate receptor 4 (mGluR4) is an emerging target for the treatment of Parkinson's disease (PD). However, since the discovery of its therapeutic potential, no ligand has been successfully developed enough to be tested in the clinic. In the present paper, we report for the first time the medicinal chemistry efforts conducted around the pharmacological tool (-)-PHCCC. This work led to the identification of compound 40, a potent and selective mGluR4 positive allosteric modulator (PAM) with good water solubility and demonstrating consistent activity across validated preclinical rodent models of PD motor symptoms after intraperitoneal administration: haloperidol-induced catalepsy in mouse and the rat 6-hydroxydopamine (6-OHDA) lesion model. Moreover, we also describe the identification of compound 60 a close analogue of compound 40 with improved pharmacokinetic profile after oral administration. On the basis of its favorable and unique preclinical profile, compound 60 (PXT002331, now foliglurax) was nominated as a candidate for clinical development.
