66155-20-2

Usage

Uses

Used in Pharmaceutical Industry:
2-(quinolin-2-yl)-4H-chromen-4-one is used as a pharmaceutical candidate for its potential antitumor activity. It has been studied for its ability to inhibit the growth and progression of various types of cancer, making it a valuable asset in the development of new cancer treatments.
Used in Anti-inflammatory Applications:
As an anti-inflammatory agent, 2-(quinolin-2-yl)-4H-chromen-4-one can be used to alleviate inflammation and reduce the associated pain and swelling. Its anti-inflammatory properties make it a potential candidate for the treatment of various inflammatory conditions.
Used in Antioxidant Applications:
2-(quinolin-2-yl)-4H-chromen-4-one exhibits antioxidant properties, which can be utilized in various applications to protect cells from oxidative stress and damage. It can be used in the development of antioxidants for medical and cosmetic purposes, as well as in the food industry to extend the shelf life of products.
Used in Antimicrobial Applications:
Due to its antimicrobial properties, 2-(quinolin-2-yl)-4H-chromen-4-one can be used in the development of new antimicrobial agents to combat bacterial infections. It can be applied in the medical field for the treatment of various infections and in the agricultural industry for crop protection.

Upstream product

• 6296-06-6 1-(2-hydroxyphenyl)-3-(2-quinolyl)propane-1,3-dione 
• 50342-01-3 quinolin-2-ylcarbonyl chloride 
• 118-93-4 o-hydroxyacetophenone 
• 5470-96-2 quinoline 2-carbaldehyde 
• 2491-36-3 2-(2-bromoacetyl)hydroxybenzene 

Relevant academic research and scientific papers

Temperature-Controlled Desulfonylative Condensation of α-Sulfonyl o-Hydroxyacetophenones and 2-Formyl Azaarenes: Synthesis of Azaaryl Aurones and Flavones

Temperature-controlled intermolecular desulfonylative condensation of α-sulfonyl o-hydroxyacetophenones with 2-formyl azaarenes (pyridines and quinolones) provides azaaryl (pyridyl and quinolyl) aurones and flavones under warming and refluxing toluene reaction conditions via the formation of the intermediate of sulfonyl chroman-4-one. The uses of various solvents are investigated for facile and efficient transformation. A plausible mechanism is proposed.

Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

The metabotropic glutamate receptor 4 (mGluR4) is an emerging target for the treatment of Parkinson's disease (PD). However, since the discovery of its therapeutic potential, no ligand has been successfully developed enough to be tested in the clinic. In the present paper, we report for the first time the medicinal chemistry efforts conducted around the pharmacological tool (-)-PHCCC. This work led to the identification of compound 40, a potent and selective mGluR4 positive allosteric modulator (PAM) with good water solubility and demonstrating consistent activity across validated preclinical rodent models of PD motor symptoms after intraperitoneal administration: haloperidol-induced catalepsy in mouse and the rat 6-hydroxydopamine (6-OHDA) lesion model. Moreover, we also describe the identification of compound 60 a close analogue of compound 40 with improved pharmacokinetic profile after oral administration. On the basis of its favorable and unique preclinical profile, compound 60 (PXT002331, now foliglurax) was nominated as a candidate for clinical development.