629616-63-3Relevant articles and documents
Bisubstrate inhibitors for the enzyme catechol O-methyltransferase (COMT): Dramatic effects of ribose modifications on binding affinity and binding mode
Lerner, Christian,Siegrist, Romain,Schweizer, Eliane,Diederich, Francois,Gramlich, Volker,Jakob-Roetne, Roland,Zuercher, Gerhard,Borroni, Edilio
, p. 1045 - 1062 (2003)
Inhibition of the enzyme catechol O-methyltransferase (COMT) is of significant interest in the therapy of Parkinson's disease. Described herein are structural analogs of the potent bisubstrate inhibitor (-)-1 (IC50 = 9 nM; Table 1) for COMT, wi
PROCESS FOR THE PREPARATION OF TENELIGLIPTIN AND ITS NOVEL INTERMEDIATES
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Page/Page column 26, (2016/01/26)
The present invention relates to a novel process for the preparation of Teneligliptin or its pharmaceutically acceptable salts and its hydrates thereof. The invention also relates to novel intermediates used in the synthesis of Teneligliptin and their preparation.