629616-63-3Relevant academic research and scientific papers
Bisubstrate inhibitors for the enzyme catechol O-methyltransferase (COMT): Dramatic effects of ribose modifications on binding affinity and binding mode
Lerner, Christian,Siegrist, Romain,Schweizer, Eliane,Diederich, Francois,Gramlich, Volker,Jakob-Roetne, Roland,Zuercher, Gerhard,Borroni, Edilio
, p. 1045 - 1062 (2003)
Inhibition of the enzyme catechol O-methyltransferase (COMT) is of significant interest in the therapy of Parkinson's disease. Described herein are structural analogs of the potent bisubstrate inhibitor (-)-1 (IC50 = 9 nM; Table 1) for COMT, wi
7-OXO-6-(SULFOOXY)-1,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXAMIDE CONTAINING COMPOUNDS AND THEIR USE IN TREATING BACTERIAL INFECTIONS
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, (2017/07/06)
Compounds of Formula (I), their preparation, and use in preventing or treating a bacterial infection are disclosed. (I)
PROCESS FOR THE PREPARATION OF TENELIGLIPTIN AND ITS NOVEL INTERMEDIATES
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, (2016/01/26)
The present invention relates to a novel process for the preparation of Teneligliptin or its pharmaceutically acceptable salts and its hydrates thereof. The invention also relates to novel intermediates used in the synthesis of Teneligliptin and their preparation.
New synthetic route to a dipeptidyl peptidase-4 inhibitor
Lafrance, Danny,Caron, Stephane
experimental part, p. 409 - 414 (2012/07/31)
A new synthetic route to a dipeptidyl peptidase-4 (DPP4) inhibitor was developed and demonstrated on a multigram scale. This approach takes advantage of the cheap and readily available Boc-trans-4-hydroxy-l-proline methyl ester as starting material which
