869490-23-3

Usage

Uses

Gosogliptin is used as a treatment for type 2 diabetes.

Upstream product

• 629616-63-3 1-(1,1-dimethylethyl) 2-methyl (2S,4R)-4-{[(4-nitrophenyl)sulfonyl]oxy}-2,3,4,5-tetrahydro-1H-pyrrole-1,2-dicarboxylate 
• 84520-67-2 (2S,4R)-4-(methylsulfonyloxy)pyrrolidine-1,2-dicarboxylic acid 1-tert-butylester-2-methylester 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 20980-22-7 N-(2-pyridinyl)piperazine 
• 1361054-85-4 C₁₇H₂₃NO₇S 
• 1361054-82-1 1-tert-butyl 2-methyl (2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidine-1,2-dicarboxylate 

Relevant academic research and scientific papers

New synthetic route to a dipeptidyl peptidase-4 inhibitor

A new synthetic route to a dipeptidyl peptidase-4 (DPP4) inhibitor was developed and demonstrated on a multigram scale. This approach takes advantage of the cheap and readily available Boc-trans-4-hydroxy-l-proline methyl ester as starting material which

Therapeutic compounds

The invention provides compounds of formula (I), prodrugs and stereoisomers thereof, and the pharmaceutically acceptable salts of the compounds, prodrugs, and stereoisomers, wherein R1, R2, R3, HET, n, Q, X, Y, and Z are as described herein; compositions thereof; and uses thereof in treating diabetic complications including diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, and the like.