629648-06-2

Upstream product

• 95715-87-0 (R)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyloxazolidine 
• 501-53-1 benzyl chloroformate 
• 100-46-9 benzylamine 
• 629648-03-9 (4S)-4-[3-oxo-5-(4'-methylphenylsulfonyl)-1-pentenyl]-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine 

Downstream Products

• 400009-40-7 (2S,2'R)-tert-butoxycarbonylamino-(1'-benzyloxycarbonyl-4'-oxopiperidin-2'-yl)-acetic acid 
• 629648-09-5 (1S,2'R)-1-(1'-benzyloxycarbonyl-4'-oxopiperidin-2'-yl)-2-(hydroxy)ethylcarbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Diastereoselective synthesis of 2-substituted-piperidin-4-ones as convenient precursors for an asymmetric approach to carbacephams

Optically active carbacephams can be efficiently prepared generating the β-lactam ring on 2-substituted-piperidin-4-ones. These can, in turn, be prepared diastereoselectively through a Michael-Michael reaction sequence initiated by benzylamine on precursors derived by Wittig reaction between serinals and 4-[(4-methylphenyl)sulfonyl]-1-(triphenylphosphoranylidene)-2-butanone.