629648-08-4Relevant academic research and scientific papers
Diastereoselective synthesis of 2-substituted-piperidin-4-ones as convenient precursors for an asymmetric approach to carbacephams
Barco, Achille,Baricordi, Nikla,Benetti, Simonetta,Biondini, Gisella,De Risi, Carmela,Pollini, Gian Piero
, p. 8439 - 8444 (2007/10/03)
Optically active carbacephams can be efficiently prepared generating the β-lactam ring on 2-substituted-piperidin-4-ones. These can, in turn, be prepared diastereoselectively through a Michael-Michael reaction sequence initiated by benzylamine on precursors derived by Wittig reaction between serinals and 4-[(4-methylphenyl)sulfonyl]-1-(triphenylphosphoranylidene)-2-butanone.
