62967-27-5Relevant academic research and scientific papers
Differences in antischistosomal and mutagenic properties between an isothiocyano- and an isocyanonitrodiphenylamine
Coulter,Bueding,Batzinger
, p. 981 - 982 (1977)
While 4 isothiocyano 4' nitrodiphenylamine has high schistosomicidal activity in vivo and is devoid of mutagenic properties in vitro, the reverse is true for the isocyano analogue of this compound; i.e., replacement of the sulfur by oxygen results in a compound that has no demonstrable antischistosomal effects and exhibits significant mutagenic activity.
Synthesis of Potential Metabolites of 4-Methyl-1-piperazine
Anjaneyulu B.
, p. 657 - 661 (2007/10/02)
4-Methyl-1-piperazine (1) is an experimental antifilarial drug.In order to investigate its metabolic fate in laboratory animals and also man several potential metabolites, arising from general metabolic conversions of 1, viz.N-oxidation (8), N-demethylation and acetylation (11) and (12), desulphuration (15), nitro group reduction to aryl amino (16) and further acetylation to arylacetamido (17), have been synthesized for identification/quantitation purposes.
