6297-20-7 Usage
Uses
Used in Oncology:
2,2-dimethyl-N-phenylhydrazinecarboxamide is used as a chemotherapeutic agent for the treatment of various types of cancers, particularly brain tumors. It functions by attaching alkyl groups to DNA, causing cross-linking and strand breaks, which lead to cell death and inhibit tumor growth.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,2-dimethyl-N-phenylhydrazinecarboxamide is used as an active pharmaceutical ingredient in the development of cancer treatment drugs. Its potent cytotoxic and mutagenic properties make it a valuable compound in the fight against cancer.
However, due to the severe side effects associated with its use, such as bone marrow suppression, gastrointestinal disturbances, and liver toxicity, proper precautions must be taken when handling and administering semustine. This includes adherence to safety protocols and guidelines to minimize risks to patients and healthcare professionals.
Check Digit Verification of cas no
The CAS Registry Mumber 6297-20-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,2,9 and 7 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 6297-20:
(6*6)+(5*2)+(4*9)+(3*7)+(2*2)+(1*0)=107
107 % 10 = 7
So 6297-20-7 is a valid CAS Registry Number.
6297-20-7Relevant academic research and scientific papers
Specificity of the Reaction of 1,1-Dimethylhydrazine with Phenyl Isocyanate
Savel'ev,Khranovskii,Veselov,Grekov,Savel'eva
, p. 96 - 98 (2007/10/03)
According to the data of IR and NMR spectroscopy and ebullioscopy, the reaction of phenyl isocyanate with a large excess of 1,1-dimethylhydrazine gives 1,1 -dimethyl-4-phenylsemicarbazide as the major product. At other reactant ratios, biuret-like structures are formed.
Reactions of 1,1-Dimethyl-4-substituted-semicarbazides with Phosgene
Cooley, James H.,Evain, Eric J.,Willett, Roger D.,Blanchette, Joan T.
, p. 1048 - 1051 (2007/10/02)
Reaction of excess phosgene with 1,1-dimethyl-4-phenylsemicarbazide, 3, gave 3-chloro-1-methyl-4-phenyl-Δ2-1,2,4-triazolin-5-one, 4.An investigation into the reaction pathway led to the surprising find that when 1 equiv of phosgene was allowed
