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NSC45721, also known as 4,6-Dichloro-2-hydroxypyrimidine, is a chemical compound that serves as a valuable building block in the synthesis of various pharmaceuticals and bioactive molecules. It is an isomer of 5-Chlorouracil (C423775) and possesses unique structural properties that make it a versatile component in the development of new drugs and therapeutic agents.

6297-80-9

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6297-80-9 Usage

Uses

Used in Pharmaceutical Synthesis:
NSC45721 is used as a building block for the preparation of diaminopyrimidinone IRAK4 inhibitors. These inhibitors play a crucial role in modulating the activity of IRAK4, a key enzyme involved in the regulation of inflammatory responses and immune system signaling pathways. By targeting IRAK4, diaminopyrimidinone compounds can potentially be used to treat various inflammatory and autoimmune diseases.
Used in Chemical Research:
As an isomer of 5-Chlorouracil (C423775), NSC45721 is also utilized in chemical research to study the effects of structural variations on the properties and reactivity of molecules. This knowledge can be applied to the design and synthesis of new compounds with improved pharmacological profiles and therapeutic potential.

Check Digit Verification of cas no

The CAS Registry Mumber 6297-80-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,2,9 and 7 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 6297-80:
(6*6)+(5*2)+(4*9)+(3*7)+(2*8)+(1*0)=119
119 % 10 = 9
So 6297-80-9 is a valid CAS Registry Number.
InChI:InChI=1/C4H2Cl2N2O/c5-2-1-3(6)8-4(9)7-2/h1H,(H,7,8,9)

6297-80-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4,6-Dichloropyrimidin-2(1H)-one

1.2 Other means of identification

Product number -
Other names 4,6-dichloro-1H-pyrimidin-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6297-80-9 SDS

6297-80-9Upstream product

6297-80-9Relevant academic research and scientific papers

PEPTIDYLARGININE DEIMINASES (PAD) INHIBITORS

-

Page/Page column 84-85, (2014/12/12)

The present invention relates to compounds of the formula (I): as inhibitors of peptidylarginine deiminases (PADs). It also concerns their use in therapy, particularly in the prophylaxis or treatment of neural injury, and other conditions including cancer, multiple sclerosis, glaucoma, arthritis, rheumatoid arthritis lupus, Alzheimer's disease, and ulcerative colitis.

Discovery of phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H- pyrimidin-2-one, an effective antithrombotic agent without associated bleeding and insulin resistance

Giordanetto, Fabrizio,Wallberg, Andreas,Ghosal, Saswati,Iliefski, Tommy,Cassel, Johan,Yuan, Zhong-Qing,Von Wachenfeldt, Henrik,Andersen, Soren M.,Inghardt, Tord,Tunek, Anders,Nylander, Sven

supporting information, p. 6671 - 6676,6 (2012/12/12)

Structure-based evolution of the original fragment leads resulted in the identification of 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2- methylmorpholin-4-yl]-1H-pyrimidin-2-one, (S)-21, a potent, selective phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor with favourable in vivo antiplatelet effect. Despite its antiplatelet action, (S)-21 did not significantly increase bleeding time in dogs. Additionally, due to its enhanced selectivity over p110α, (S)-21 did not induce any insulin resistance in rats.

Pteridines. Part XLI. Synthesis and Properties of 6,7,8-Trimethyl-4-thiolumazine

Huebsch, Walter,Pfleiderer, Wolfgang

, p. 738 - 743 (2007/10/02)

The first representative of the 8-substituted 4-thiolumazine series has been synthesized.In a sequence of reactions, 4,6-dichloropyrimidin-2-(1H)-one (1) is first converted into 4-chloro-6-(methylamino)pyrimidin-2(1H)-one (6), then the Cl-atom displaced b

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