62983-44-2Relevant articles and documents
Radiosynthesis and preliminary biodistribution in mice of 6-deoxy-6-[ 131I]iodo-L-ascorbic acid
Kim, Jintaek,Yamamoto, Fumihiko,Karasawa, Satoru,Mukai, Takahiro,Maeda, Minoru
, p. 366 - 371 (2009)
An ascorbate analog labeled with iodine-131, 6-deoxy- 6-[ 131I]iodo-L-ascorbic acid was prepared for evaluation as an in vivo tracer of L-ascorbic acid. The no-carrier-added radiosynthesis was conducted by nucleophilic bromine-iodine exchange between the brominated precursor and sodium [131I]iodide in 2-pentanone at 130-140°C. HPLC purification using a reversephase column gave 6-deoxy-6-[131I]iodo-L-ascorbic acid in radiochemical yield of 36-60% with high radiochemical purity and satisfactory-specific radioactivity in a total preparation time of 90 min. Biodistribution studies in fibrosarcoma-bearing mice showed a high uptake in the adrenal glands, accompanied by low activity of tumor accumulation, accumulation properties similar to previous results obtained with 14C-labeled ascorbic acid and 6-deoxy-6-[18F]fluoro-L-ascorbic acid, in spite of high level of deiodination. Copyright
Prodrugs and conjugates of thiol-and selenol-containing compounds and methods of use thereof
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Page 6, (2008/06/13)
Disclosed is a prodrugs of the formula: where A is a sulfur or a selenium, and R is derived from a mono- di- or oligo- saccharide. Also disclosed is a prodrug of the formulas; where A is sulfur or selenium, R′ is derived from a sugar and R′ has the formula (CHOH)nCH2OH, where n is 1 to 5, or R′ is an alkyl or aryl group, or R′ is ═O, and the R″ groups may be the same or different and may be hydrogen, alkyl, alkoxy, carboxy. Also disclosed is a conjugate of an antioxidant vitamin and a thiolamine or selenolamine. Also disclosed is a prodrug of the formula; where A is sulfur or selenium, and R′ is derived from a sugar and R′ has the formula (CHOH)nCH2OH, where n is 1 to 5, or R′ is also be an alkyl or aryl group, or R′ is ═O, and R?is an alkoxy, or an amine group. Also disclosed is a prodrug of the formula: R is COOH or H, and R′ is derived from a sugar and R′ has the formula (CHOH)nCH2OH, where n is 1 to 5, or R′ is an alkyl or aryl group, or R′ is ═O.
Synthesis and properties of 6-deoxy-6-halogeno-derivatives of L-ascorbic acid
Kiss,Berg,Dirscherl,et al.
, p. 1728 - 1739 (2007/10/02)
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