6299-93-0

Usage

Uses

Used in Pharmaceutical Industry:
NSC45056 is used as a therapeutic agent for various conditions, including cancer, infectious diseases, and autoimmune disorders. Its anti-cancer activity is mediated through mechanisms such as inhibition of cell proliferation, induction of apoptosis, and inhibition of angiogenesis.
Used in Cancer Treatment:
NSC45056 is used as an anti-cancer agent, targeting a variety of cancer types by inhibiting cell proliferation, inducing apoptosis, and preventing the formation of new blood vessels that supply tumors.
Used in Infectious Disease Treatment:
NSC45056 is used as an antiviral agent, exhibiting potential activity against various viral infections due to its ability to interfere with viral replication and reduce viral load.
Used in Autoimmune Disorder Treatment:
NSC45056 is used as an immune-modulating agent, regulating the production of cytokines and modulating immune cell function to help manage autoimmune disorders.
Used in Drug Delivery Systems:
NSC45056 can be incorporated into drug delivery systems to improve its bioavailability, targeting, and therapeutic efficacy in treating various diseases.

InChI:InChI=1/C8H9N3/c1-6-10-7-4-2-3-5-8(7)11(6)9/h2-5H,9H2,1H3

Upstream product

• 615-15-6 2-Methyl-1H-benzimidazole 
• 14674-17-0 acetic acid 2-(2-nitrophenyl)hydrazide 
• 6299-91-8 N'-(2-aminophenyl)acetohydrazide 

Downstream Products

• 127845-13-0 1-Benzylideneamino-2-methylbenzimidazole 
• 40995-27-5 1-(acetamido)-2-(methyl)benzimidazole 
• 75380-62-0 2-phenyl-4-methylpyrazolo<1,5-a>benzimidazole 
• 75380-58-4 2-phenyl-4-methyl-3-benzoylpyrazolo<1,5-a>benzimidazole 
• 869662-71-5 1-[2-(3-chloro-4-n-butoxyphenyl)ethylamino]-2-methylbenzimidazole 
• 183007-22-9 4-amino-2-phenylpyrrolo[1,2-a]benzimidazole 
• 183007-30-9 1-Benzylamino-2-methylbenzimidazole 

Relevant academic research and scientific papers

Reactions of 1-Amino-, 1-Benzylamino, and 1-Arylmethylene- Amino-2-methyl-3-phenacylbenzimidazolium Ions with Bases

1-Amino- and 1-benzylamino-2-methyl-3-phenacylbenzimidazolium ions undergo ring closure to give hitherto unknown 4-amino- and 4-benzylamino-2-arylpyrrolo[1,2-a]benzimidazoles when heated in an aqueous solution of sodium bicarbonate. Under the same conditions, 1-arylmethyleneamino analogs form pseudobases occurring in the open-chain tautomeric form.

Electrochemical reduction of o-nitrophenylhydrazides into 1,2,4-benzotriazines.

Phenylhydroxylamines, obtained in aqueous medium, by electroreduction of o-nitrophenylhydrazides (o-NO2-C6H4-NH-NHCOR), undergo a disproportionation reaction leading finally to the corresponding o-amino compound; the latter partially rearranges into an o-amidophenylhydrazine (o-RCONH-C6H4-NH-NH2).In a basic media, the disproportionation reaction is concurrent with a ring closure of the intermediate hydroxylamine giving rise to a 1,2,4-benzotriazine.The latter is also obtained by anodic oxidation of the amine, mixed with anilide resulting from the hydrazine oxidation.Electroreduction, immediately followed by an anodic oxidation gives rise to about 50percent yield in the expected triazine.In an acidic media, disproportionation is faster, but the resulting amine undergoes a ring closure reaction into dihydrobenzotriazine when R = H or CH3.Subsequent oxidation of the latter gives rise to 75percent yield of the triazine, mixed with N-aminobenzimidazole resulting from the hydrazine.When R = Ph, the amine is stable but only very poor yields of triazine are obtained by anodic oxidation; the major evolution is probably the formation of an unstable benzoylbenzotriazole.Key words: cyclic voltammetry, controlled potential reduction and oxidation, 1,2,4-benzotriazine, 1-amino-2-alkylbenzimidazoles, organic electrosynthesis.

SYNTHESIS OF 4-ALKYLPYRAZOLOBENZIMIDAZOLES

2,4-Disubstituted pyrazolobenzimidazoles were obtained by the action of carboxylic acid anhydrides on 1-amino-2-methyl-3-alkylbenzimidazolium salts in the presence of potassium carbonate.