6299-93-0

Basic information

• Product Name: NSC45056
• Synonyms: NSC45056;1H-Benzimidazol-1-amine,2-methyl-(9CI);1-Amino-2-methylbenzimidazole
• CAS NO: 6299-93-0
• Molecular Formula: C₈H₉N₃
• Molecular Weight: 147.18
• Product Categories: BENZIMIDAZOLE
• Mol File: 6299-93-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 334.9 °C at 760 mmHg
• Flash Point: 156.3 °C
• Appearance: /
• Density: 1.27 g/cm³
• Vapor Pressure: 0.000124mmHg at 25°C
• Refractive Index: 1.667
• CAS DataBase Reference: NSC45056(CAS DataBase Reference)
• NIST Chemistry Reference: NSC45056(6299-93-0)
• EPA Substance Registry System: NSC45056(6299-93-0)

Safety Data

• Hazardous Substances Data: 6299-93-0(Hazardous Substances Data)

Usage

General Description

NSC45056, also known as andrographolide, is a naturally occurring diterpenoid compound found in the herb Andrographis paniculata. It has been used in traditional medicine for its anti-inflammatory, antiviral, and antioxidant properties. Studies have shown that NSC45056 has potential as a therapeutic agent for a variety of conditions including cancer, infectious diseases, and autoimmune disorders. Its anti-cancer activity is thought to be mediated through various mechanisms including inhibition of cell proliferation, induction of apoptosis, and inhibition of angiogenesis. Additionally, NSC45056 has been found to exhibit immune-modulating effects by regulating the production of cytokines and modulating immune cell function. Overall, NSC45056 shows promise as a multifunctional compound with potential therapeutic applications in various diseases.

InChI:InChI=1/C8H9N3/c1-6-10-7-4-2-3-5-8(7)11(6)9/h2-5H,9H2,1H3

Upstream product

• 14674-17-0 acetic acid 2-(2-nitrophenyl)hydrazide 
• 6299-91-8 N'-(2-aminophenyl)acetohydrazide 
• 615-15-6 2-Methyl-1H-benzimidazole 

Downstream Products

• 127845-13-0 1-Benzylideneamino-2-methylbenzimidazole 
• 869662-71-5 1-[2-(3-chloro-4-n-butoxyphenyl)ethylamino]-2-methylbenzimidazole 
• 75380-58-4 2-phenyl-4-methyl-3-benzoylpyrazolo<1,5-a>benzimidazole 
• 75380-62-0 2-phenyl-4-methylpyrazolo<1,5-a>benzimidazole 
• 183007-22-9 4-amino-2-phenylpyrrolo[1,2-a]benzimidazole 
• 183007-30-9 1-Benzylamino-2-methylbenzimidazole 

Relevant articles and documents

Reactions of 1-Amino-, 1-Benzylamino, and 1-Arylmethylene- Amino-2-methyl-3-phenacylbenzimidazolium Ions with Bases

1-Amino- and 1-benzylamino-2-methyl-3-phenacylbenzimidazolium ions undergo ring closure to give hitherto unknown 4-amino- and 4-benzylamino-2-arylpyrrolo[1,2-a]benzimidazoles when heated in an aqueous solution of sodium bicarbonate. Under the same conditions, 1-arylmethyleneamino analogs form pseudobases occurring in the open-chain tautomeric form.

SYNTHESIS OF 4-ALKYLPYRAZOLOBENZIMIDAZOLES

2,4-Disubstituted pyrazolobenzimidazoles were obtained by the action of carboxylic acid anhydrides on 1-amino-2-methyl-3-alkylbenzimidazolium salts in the presence of potassium carbonate.