63002-57-3

Basic information

• Product Name: 2-CHLOROMETHYL-5-(3-NITRO-PHENYL)-[1,3,4]OXADIAZOLE
• Synonyms: 3-[5-(Chloromethyl)-1,3,4-oxadiazol-2-yl]nitrobenzene;2-(Chloromethyl)-5-[3-(trifluoromethyl)phenyl]-1,3,4-oxadiaz
• CAS NO: 63002-57-3
• Molecular Formula: C₉H₆ClN₃O₃
• Molecular Weight: 239.62
• Mol File: 63002-57-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 399.9°C at 760 mmHg
• Flash Point: 195.6°C
• Appearance: /
• Density: 1.465g/cm³
• Vapor Pressure: 3.06E-06mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 2-CHLOROMETHYL-5-(3-NITRO-PHENYL)-[1,3,4]OXADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLOROMETHYL-5-(3-NITRO-PHENYL)-[1,3,4]OXADIAZOLE(63002-57-3)
• EPA Substance Registry System: 2-CHLOROMETHYL-5-(3-NITRO-PHENYL)-[1,3,4]OXADIAZOLE(63002-57-3)

Safety Data

• Hazardous Substances Data: 63002-57-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H6ClN3O3/c10-5-8-11-12-9(16-8)6-2-1-3-7(4-6)13(14)15/h1-4H,5H2

Upstream product

• 618-98-4 ethyl 3-nitrobenzoate 
• 79-11-8 chloroacetic acid 
• 618-94-0 3-nitrobenzoic acid hydrazide 
• 33512-94-6 m-nitrobenzhydroxamoyl chloride 
• 137557-28-9 3-(3-Nitro-phenyl)-1-oxa-2,4-diaza-spiro[4.7]dodec-2-en-4-ylamine 
• 137557-26-7 8-Methyl-3-(3-nitro-phenyl)-1-oxa-2,4-diaza-spiro[4.5]dec-2-en-4-ylamine 
• 137557-27-8 3-(3-Nitro-phenyl)-1-oxa-2,4-diaza-spiro[4.6]undec-2-en-4-ylamine 
• 126175-98-2 3-(3-Nitro-phenyl)-1-oxa-2,4-diaza-spiro[4.5]dec-2-en-4-ylamine 
• 137557-29-0 5,5-Dimethyl-3-(3-nitro-phenyl)-[1,2,4]oxadiazol-4-ylamine 
• 121-92-6 3-nitrobenzoic acid 
• 63002-52-8 3-Nitro-benzoic acid N'-(2-chloro-acetyl)-hydrazide 
• 541-88-8 Chloroacetic anhydride 
• 126175-90-4 3-(3-Nitro-phenyl)-1-oxa-2,4-diaza-spiro[4.4]non-2-en-4-ylamine 
• 137557-40-5 2-Chloro-N-[3-(3-nitro-phenyl)-1-oxa-2,4-diaza-spiro[4.7]dodec-2-en-4-yl]-acetamide 

Relevant articles and documents

Synthesis and antitumor activities of novel hybrid molecules containing 1,3,4-oxadiazole and 1,3,4-thiadiazole bearing Schiff base moiety

A series of novel hybrid molecules containing 1,3,4-oxadiazole and 1,3,4-thiadiazole bearing Schiff base moiety were designed, synthesized and evaluated for their in vitro antitumor activities against SMMC-7721, MCF-7 and A549 human tumor cell lines by CCK-8 assay. The bioassay results demonstrated that most of the tested compounds showed potent antitumor activities, and some compounds exhibited stronger effects than positive control 5-fluorouracil (5-FU) against various cell lines. Among these compounds, compound 8d showed the best inhibitory effect against SMMC-7721 cells, with IC50 value of 2.84 μM. Compounds 8k and 8n displayed highly effective antitumor activities against MCF-7 cells, with IC50 values of 4.56 and 4.25 μM, respectively. Compounds 8a and 8n exhibited significant antiproliferative activity against A549 cells, with IC50 values of 4.11 and 4.13 μM, respectively. The pharmacological results suggest that the substituents of phenyl ring on the 1,3,4-oxadiazole are vital for modulating antiproliferative activities against various tumor cell lines.

Ring Transformations of Heterocycles. Part 1. Transformation of 4-Amino-Δ2-1,2,4-oxadiazolines into 1,3,4-Oxadiazoles

3-Aryl-4-amino-Δ2-1,2,4-oxadiazolines 3 and their N-chloroacetyl derivatives 4, upon treatment with chloroacetic anhydride in refluxing toluene, afford 2-chloromethyl-5-aryl-1,3,4-oxadiazoles 5, suggesting the conversion sequence 3 -> 4 -> 5.The generality of the new ring transformation 4 -> 5 is supported similar conversion of other 4-(acylamino)-1,2,4-oxadiazolines 8 to 1,3,4-oxadiazoles 9.