630110-38-2

Upstream product

• 120-72-9 indole 
• 22980-09-2 indolyl-3-glyoxylyl chloride 
• 107634-85-5 N-(2-(1H-indol-3-yl)ethyl)-2-(1H-indol-3-yl)-2-oxoacetamide 
• 98-09-9 benzenesulfonyl chloride 

Downstream Products

• 630110-40-6 1,1'-bis(benzenesulfonyl)coscinamide B 
• 630110-39-3 1,1'-bis(benzenesulfonyl)-8-bromodihydrocoscinamide B 

Relevant academic research and scientific papers

Concise synthesis of coscinamide B, a bisindolic enamide from marine sponge

An efficient, four-step synthesis of coscinamide B (2) from tryptamine is reported, in which a one-pot benzylic bromination and subsequent in situ dehydrobromination in the absence of an added base is the key step.

Synthesis of marine alkaloid: 8,9-Dihydrocoscinamide B and its analogues as Novel class of antileishmanial agents

A series of marine alkaloid 8,9-dihydrocoscinamide B, its analogues and indolylglyoxylamide derivatives have been synthesized and screened for their in vitro antileishmanial activity profile in promastigote and amastigote models. Compounds 7 and 10 have shown 99-100% inhibition against promastigotes and 97-98% inhibition against amastigotes at a concentration of 10 μg/ml.