630116-07-3Relevant academic research and scientific papers
Dopamine D4 Receptor-Selective Compounds Reveal Structure-Activity Relationships that Engender Agonist Efficacy
Keck, Thomas M.,Free, R. Benjamin,Day, Marilyn M.,Brown, Sonvia L.,Maddaluna, Michele S.,Fountain, Griffin,Cooper, Charles,Fallon, Brooke,Holmes, Matthew,Stang, Christopher T.,Burkhardt, Russell,Bonifazi, Alessandro,Ellenberger, Michael P.,Newman, Amy H.,Sibley, David R.,Wu, Chun,Boateng, Comfort A.
, p. 3722 - 3740 (2019)
The dopamine D4 receptor (D4R) plays important roles in cognition, attention, and decision making. Novel D4R-selective ligands have promise in medication development for neuropsychiatric conditions, including Alzheimer's d
Acetamides and benzamides that are useful in treating sexual dysfunction
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, (2008/06/13)
The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3- methylphenyl)acetamides: Selective dopamine D4 receptor agonists
Matulenko, Mark A.,Hakeem, Ahmed A.,Kolasa, Teodozyi,Nakane, Masaki,Terranova, Marc A.,Uchic, Marie E.,Miller, Loan N.,Chang, Renjie,Donnelly-Roberts, Diana L.,Namovic, Marian T.,Moreland, Robert B.,Brioni, Jorge D.,Stewart, Andrew O.
, p. 3471 - 3483 (2007/10/03)
Diaryl piperazine acetamides were identified as potent and selective dopamine D4 receptor agonists. Our strategy is based on an amide bond reversal of an acid sensitive, dopamine D4 receptor partial agonist, PD 168077. This reversal provided compounds with excellent potency and improved stability. Systematic evaluation of the substitution on the aryl piperazine portion revealed a significant effect on functional activity. The synthesis and biological activity of these new dopamine D4 agonists is discussed.
Acetamides and benzamides that are useful in treating sexual dysfunction
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Page 66, (2008/06/13)
The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
Acetamides and benzamides that are useful in treating sexual dysfunction
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Page 42, (2010/02/06)
The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
