630123-64-7Relevant academic research and scientific papers
Arylsulfonamide pyrimidines as VLA-4 antagonists
Xu, Ying-Zi,Konradi, Andrei W.,Bard, Frederique,Dappen, Michael,Dofiles, Lilibeth,Dreyer, Mark,Gallager, Ian,Garrido, Caroline,Krimm, Mike,Liao, Zhenmei,Messersmith, Elizabeth,Mutter, Linda,Pleiss, Michael A.,Samant, Bhushan,Semko, Christopher M.,Smith, Jennifer,Stappenbeck, Frank,Stupi, Brian,Vandervert, Chris,Welch, Brent,Wipke, Brian,Yednock, Ted
, p. 3070 - 3074 (2013/06/27)
A series of (S)-2-(2-(diethylamino)-5-(N-alkyl-N-sulfonamido)pyrimidin-4- ylamino)-3-(4-(carbamoyloxy)phenyl)propanoic acid is discovered as orally available VLA-4 antagonists. Representative compounds 11b and 11p showed efficacy in multiple in vivo anima
HETEROCYCLIC COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY α4 INTEGRINS
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Page 34, (2008/06/13)
Disclosed are compounds which bind α4 integrins, preferably VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by α4 integrins, preferably VLA-4. Such compounds are useful in the treatment of
