630131-47-4

Basic information

• Product Name: (S)-4-hydroxy-3-(7-hydroxy-1,1-dioxo-1,4-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-5-methyl-1-(3-methylbutyl)-5-(1-methylethyl)-1,5-dihydropyrrol-2-one
• Synonyms: (S)-4-hydroxy-3-(7-hydroxy-1,1-dioxo-1,4-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-5-methyl-1-(3-methylbutyl)-5-(1-methylethyl)-1,5-dihydropyrrol-2-one
• CAS NO: 630131-47-4
• Molecular Weight: 421.517
• Mol File: 630131-47-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-4-hydroxy-3-(7-hydroxy-1,1-dioxo-1,4-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-5-methyl-1-(3-methylbutyl)-5-(1-methylethyl)-1,5-dihydropyrrol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-hydroxy-3-(7-hydroxy-1,1-dioxo-1,4-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-5-methyl-1-(3-methylbutyl)-5-(1-methylethyl)-1,5-dihydropyrrol-2-one(630131-47-4)
• EPA Substance Registry System: (S)-4-hydroxy-3-(7-hydroxy-1,1-dioxo-1,4-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-5-methyl-1-(3-methylbutyl)-5-(1-methylethyl)-1,5-dihydropyrrol-2-one(630131-47-4)

Safety Data

• Hazardous Substances Data: 630131-47-4(Hazardous Substances Data)

Upstream product

• 4378-19-2 (S)-α-Methylvaline 
• 53940-82-2 (R)-2-amino-2,3-dimethylbutanoic acid 

Relevant articles and documents

A highly efficient, asymmetric synthesis of benzothiadiazine-substituted tetramic acids: Potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase

(Chemical Equation Presented) An efficient two-pot, asymmetric synthesis of benzothiadiazine-substituted tetramic acids is reported. Starting from commercially available α-amino acids or esters, reductive amination followed by a novel one-pot amide bond formation/Dieckmann cyclization provided the desired products in high yield and optical purity. An analogous solid-phase approach to the same targets is also presented. These compounds were found to be potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.