63017-06-1

Upstream product

• 21120-36-5 1-fluoroethyl phenyl ketone 
• 108221-67-6 ethyl 2-bromo-2-fluoropropionate 
• 93-55-0 1-phenyl-propan-1-one 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 

Downstream Products

• 76650-17-4 1-Phenyl-1,1-dipropoxy-propan-2-one 
• 57711-28-1 1,1-dimethoxy-1-phenylpropan-2-one 
• 73611-86-6 1,1-diethoxy-1-phenyl-2-propanone 
• 73611-87-7 1,1-Diisopropoxy-1-phenyl-propan-2-one 
• 947504-06-5 (E)-N-(2-bromo-2-fluoro-1-phenylpropylidene)isopropylamine 
• 7624-24-0 1-methoxy-1-phenyl-acetone 
• 76650-19-6 1-Ethoxy-1-isopropoxy-1-phenyl-propan-2-one 
• 76650-18-5 1-Chloro-1-ethoxy-1-phenyl-propan-2-one 
• 947504-16-7 N-(2-bromo-2-fluoro-1-phenylpropyl)-N-isopropylamine 

Relevant academic research and scientific papers

Synthesis of 3-substituted 2-fluoro- And 2,2-difluoroaziridines

A new route for the synthesis of stable 3-alkyl- and 3-aryl-2(,2)-(di) fluoroaziridines was developed by hydride reduction of novel α-bromo- and α-chloro-α(,α)-(di)fluoroketimines and subsequent ring closure of β-fluorinated β-chloro- and β-bromoamines. T

Rearrangement of 1-Aryl-2,2-dihalo-1-alkanones

Reaction of 1-aryl-2,2-dichloro-1-alkanones with alkoxides in the corresponding alcohol afforded a mixture of 1-aryl-2,2-dialkoxy-1-alkanones and 1-aryl-1,1-dialkoxy-2-alkanones.The mechanism was shown to proceed via α-chloro-α'-alkoxy epoxides, which rearranged into 1-alkoxy-1-aryl-1-chloro-2-alkanones, the latter giving the final compounds via either another epoxide intermediate or a solvolysis mechanism. α,α-Dibromo- and α-bromo-α-chloroalkyl aryl ketones behaved analogously, but α-bromo-α-fluoro- and α-chloro-α-fluoroalkyl aryl ketones gave exclusively solvolysis of initially formed 1-alkoxy-1-aryl-1-fluoro-2-alkanones, resulting in rearranged 1-aryl-1,1-dialkoxy-2-alkanones. α,α-Difluoroalkyl aryl ketones did not rearrange but underwent reduction of the carbonyl function on treatment with sodium methoxide in methanol.The influence of varying factors, such as the steric requirements of the alkoxide and the substrate, the concentration of the alkoxide, the aromatic substituent, the temperature, and the halogens, was investigated and correlated to the mechanism involved.

REGIOSPECIFIC SYNTHESIS OF α-KETOACETALS BY REARRANGEMENT OF α-BROMO-α-FLUOROKETONES

α-Ketoacetals, derived from alkylaryl-α-diones and with acetalized benzoyl moiety, were synthesized by alkoxide induced rearrangement of α-bromo-α-fluoroalkylarylketones.