63017-96-9

Upstream product

• 616-05-7 2-bromohexanoic acid 
• 100-61-8 N-methylaniline 
• 2051-49-2 n-hexanoic anhydride 
• 121-69-7 N,N-dimethyl-aniline 
• 142-61-0 Hexanoyl chloride 
• 142-62-1 hexanoic acid 

Downstream Products

• 63017-99-2 N-Methyl-N-phenyl-2-(methylthio)capronamid 
• 93766-61-1 2-(3-Benzenesulfinyl-1-hydroxy-propyl)-hexanoic acid methyl-phenyl-amide 
• 93766-78-0 5-Benzenesulfinyl-2-butyl-cyclopent-2-enone 
• 94727-51-2 5-Benzenesulfinyl-2-butyl-5-methyl-cyclopent-2-enone 
• 55980-82-0 2-Phenylsulfinyl-5-n-butylcyclopentanon 
• 92173-32-5 2-(3-Benzenesulfinyl-propyl)-hexanoic acid methyl-phenyl-amide 
• 20614-71-5 2-pentylbenzo[d]thiazole 

Relevant academic research and scientific papers

Amide Bond Formation Catalyzed by Recyclable Copper Nanoparticles Supported on Zeolite Y under Mild Conditions

A series of catalysts based on supported copper nanoparticles have been prepared and tested in the amide bond formation from tertiary amines and acid anhydrides, in the presence of tert-butyl hydroperoxide as an oxidant. Copper nanoparticles on zeolite Y (CuNPs/ZY) was found to be the most efficient catalyst for the synthesis of amides, working in acetonitrile as solvent, under ligand- and base-free conditions in air. The products were obtained in good to excellent yields and in short reaction times. The CuNPs/ZY system also exhibited higher catalytic activity than some commercially available copper and iron sources and it was reused in ten reaction cycles without any further pre-treatment. This methodology has been successfully scaled-up to a gram scale with no detriment to the yield.

An efficient synthesis of benzothiazole using tetrabromomethane as a halogen bond donor catalyst

An efficient and mild protocol has been developed for the synthesis of 2-substituted benzothiazole under solvent- and metal-free conditions using CBr4 as the catalyst. This process involves the activation of a thioamide through halogen bond formation between the sulphur atom of the thioamide and bromine atom of the CBr4 molecule. The presence of halogen-bonding interaction between N-methylthioamides and tetrabromomethane has been demonstrated with several control experiments, spectroscopic analysis and density functional theory (DFT). This methodology has a wide substrate scope for the synthesis of both 2-alkyl and 2-aryl substituted benzothiazoles.

Method for preparing N-aryl amide without solvent and catalyst

The invention discloses a method for preparing N-aryl amide without a solvent and a catalyst. The method is characterized by obtaining the N-aryl amide under solvent-free and catalyst-free action; a molar ratio of substituted meldrum acid and arylamine is (1 to 5) to (5 to 1). According to the method disclosed by the invention, the defects that acyl chloride, anhydride, a dehydration coupling reagent, the solvent, a phase transfer catalyst or a metal catalyst, and the like are required to be adopted in the prior art are overcome; the method has the following advantages that (1) the substituted meldrum acid is used as an acylating agent, so that pre-activation on carboxylic acid or use of the dehydration coupling reagent is avoided; (2) due to easiness in preparation of the substituted meldrum acid, certain difficult-to-obtain or expensive carboxylic acid and activated derivatives are prevented from being used; (3) a solvent-free mode is adopted, so that the use of a toxic organic solvent or emission of wastewater is avoided; (4) no acid, base or metal catalysts exist, the influence of the acid and the base on sensitive groups and equipment and the residue of metal ions in a product are avoided. A synthesis method disclosed by the invention can play an important role in industrial production for preparing the N-aryl amide and particularly for preparing the N-aryl amide with complex carboxylic acid.

Transfer Hydro-dehalogenation of Organic Halides Catalyzed by Ruthenium(II) Complex

A simple and efficient Ru(II)-catalyzed transfer hydro-dehalogenation of organic halides using 2-propanol solvent as the hydride source was reported. This methodology is applicable for hydro-dehalogenation of a variety of aromatic halides and α-haloesters and amides without additional ligand, and quantitative yields were achieved in many cases. The potential synthetic application of this method was demonstrated by efficient gram-scale transformation with catalyst loading as low as 0.5 mol %.

Conversion of α-Anilino Alkenenitriles to Amides by Chemoselective Palladium-Catalyzed Arylations

The reactions of α-anilino alkenenitriles with iodobenzene catalyzed by palladium gave amides and benzonitrile. A general mechanism is proposed to explain the chemoselective arylation at the cyano group.