6302-68-7

Basic information

• Product Name: 5-methyl-1,2,4-triazin-3-amine
• Synonyms: 5-methyl-1,2,4-triazin-3-amine;1,2,4-Triazin-3-amine,5-methyl-(9CI)
• CAS NO: 6302-68-7
• Molecular Formula: C4H6N4
• Molecular Weight: 110.12
• Product Categories: VARIOUSAMINE
• Mol File: 6302-68-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-methyl-1,2,4-triazin-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-1,2,4-triazin-3-amine(6302-68-7)
• EPA Substance Registry System: 5-methyl-1,2,4-triazin-3-amine(6302-68-7)

Safety Data

• Hazardous Substances Data: 6302-68-7(Hazardous Substances Data)

Upstream product

• 1937-19-5 1-aminoguanidine hydrochloride 
• 78-98-8 2-oxopropanal 
• 2582-30-1 aminoguanidine bicarbonate 
• 2200-97-7 aminoguanidine hydrogencarbonate 

Downstream Products

• 107107-90-4 3-Amino-5-phenylsulfonylmethyl-1,2,4-triazine 

Relevant articles and documents

Reactivity, Selectivity, and Reaction Mechanisms of Aminoguanidine, Hydralazine, Pyridoxamine, and Carnosine as Sequestering Agents of Reactive Carbonyl Species: A Comparative Study

Reactive carbonyl species (RCS) are endogenous or exogenous byproducts involved in the pathogenic mechanisms of different oxidative-based disorders. Detoxification of RCS by carbonyl quenchers is a promising therapeutic strategy. Among the most studied quenchers are aminoguanidine, hydralazine, pyridoxamine, and carnosine; their quenching activity towards four RCS (4-hydroxy-trans-2-nonenal, methylglyoxal, glyoxal, and malondialdehyde) was herein analyzed and compared. Their ability to prevent protein carbonylation was evaluated in vitro by using an innovative method based on high-resolution mass spectrometry (HRMS). The reactivity of the compounds was RCS dependent: carnosine efficiently quenched 4-hydroxy-trans-2-nonenal, pyridoxamine was particularly active towards malondialdehyde, aminoguanidine was active towards methylglyoxal and glyoxal, and hydralazine efficiently quenched all RCS. Reaction products were generated in vitro and were characterized by HRMS. Molecular modeling studies revealed that the reactivity was controlled by specific stereoelectronic parameters that could be used for the rational design of improved carbonyl quenchers.

Detection of α-Dicarbonyl compounds in Maillard reaction systems and in vivo

α-Dicarbonyl compounds are of major interest in food chemistry and biochemistry as important precursors of, for example, protein modifications and flavor. Due to their high reactivity most of the published structures were identified and quantitated as stable derivatives after reaction with trapping reagents. However, the present study showed for the first time that the trapping reagents are of dramatic impact on the final qualitative and quantitative α-dicarbonyl spectrum. As important representatives, aminoguanidine and o-phenylenediamine were used to compare trapping characteristics and to monitor the dicarbonyl structures arising from the degradation of an Amadori compound. Dicarbonyl structures with a reductone moiety could not be or were only insufficiently detected by slow-reacting reagents such as aminoguanidine. On the other hand, fast-reacting chemicals such as o-phenylenediamine imposed high oxidative stress on the investigated system and led to enhanced or false positive formation of dicarbonyl compounds generated by oxidative pathways.