6304-20-7

Basic information

• Product Name: 1-pyridin-4-ylbutan-2-one
• Synonyms: 1-pyridin-4-ylbutan-2-one;1-(4-Pyridinyl)-2-butanone
• CAS NO: 6304-20-7
• Molecular Formula: C9H11NO
• Molecular Weight: 149.19
• Mol File: 6304-20-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 249.4°C at 760 mmHg
• Flash Point: 111.1°C
• Appearance: /
• Density: 1.024g/cm³
• Vapor Pressure: 0.0229mmHg at 25°C
• Refractive Index: 1.505
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Sparingly)
• CAS DataBase Reference: 1-pyridin-4-ylbutan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-pyridin-4-ylbutan-2-one(6304-20-7)
• EPA Substance Registry System: 1-pyridin-4-ylbutan-2-one(6304-20-7)

Safety Data

• Hazardous Substances Data: 6304-20-7(Hazardous Substances Data)

Usage

Uses

1-(4-Pyridinyl)-2-butanone is an intermediate in the synthesis of Milrinone (M344680) and Amrinone (A635000) analogues used as an cardiotonic agent.

InChI:InChI=1/C9H11NO/c1-2-9(11)7-8-3-5-10-6-4-8/h3-6H,2,7H2,1H3

Upstream product

• 108-89-4 picoline 
• 105-37-3 Ethyl propionate 
• 79-03-8 propionyl chloride 
• 78-93-3 butanone 

Relevant articles and documents

Discovery of potent and selective CDK8 inhibitors through FBDD approach

A fragment library screen was carried out to identify starting points for novel CDK8 inhibitors. Optimization of a fragment hit guided by co-crystal structures led to identification of a novel series of potent CDK8 inhibitors which are highly ligand efficient, kinase selective and cellular active. Compound 16 was progressed to a mouse pharmacokinetic study and showed good oral bioavailability.

Process for preparing certain 1-lower alkanoyl or benzoyl-4-(lower alkanoyl or benzoyl-methylidene)-1,4-dihydropyridines or acid addition salts thereof

There is described a novel process for preparing 4-pyridinylmethyl ketones of formula (I) STR1 wherein R is alkyl, aryl or aralkyl. The process involves hydrolysis of a compound STR2 generated by reaction of an acylating agent with 4-methylpyridine. The acylating agent may be selected from compounds of formula R-CO-X and R-CO-O-CO-R where R is as defined above and X represents halogen. Compounds of formula I have utility in the preparation of a variety of products, including pharmaceutically active 1,2-dihydro-6-R-2-oxo-5 pyridinyl compounds.

5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as cardiotonics and their preparation

1-R-5-PY-6-Q-1H-pyrazolo[3,4-b]pyridin-3-amines or pharmaceutically-acceptable acid-addition salts thereof, which are useful as cardiotonics, are prepared by reacting a 2-halo-5-PY-6-Q-nicotinonitrile with 1-R-hydrazine, where R is hydrogen, lower-alkyl, lower-hydroxyalkyl, 2,3-dihydroxypropyl or lower-alkoxyalkyl, Q is hydrogen or lower-alkyl, and PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents. Also shown are cardiotonic compositions and method for increasing cardiac contractility using said compounds or salts.