6306-25-8

Basic information

• Product Name: 4-UREIDO-BENZOIC ACID
• Synonyms: Nsc22974
• CAS NO: 6306-25-8
• Molecular Formula: C₈H₈N₂O₃
• Molecular Weight: 180.16
• Mol File: 6306-25-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 371.3°C at 760 mmHg
• Flash Point: 178.3°C
• Appearance: /
• Vapor Pressure: 3.61E-06mmHg at 25°C
• CAS DataBase Reference: 4-UREIDO-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-UREIDO-BENZOIC ACID(6306-25-8)
• EPA Substance Registry System: 4-UREIDO-BENZOIC ACID(6306-25-8)

Safety Data

• Hazardous Substances Data: 6306-25-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H8N2O3/c9-8(13)10-6-3-1-5(2-4-6)7(11)12/h1-4H,(H,11,12)(H3,9,10,13)/p-1

Upstream product

• 590-28-3 potassium cyanate 
• 7732-18-5 water 
• 22669-27-8 p-aminobenzoic acid hydrochloride 
• 30932-68-4 methyl 4-ureidobenzoate 
• 619-45-4 4-methoxycarbonyl aniline 
• 150-13-0 4-amino-benzoic acid 
• 598-50-5 N-Methylurea 
• 57-13-6 urea 
• 556-89-8 nitrourea 
• 23138-53-6 methyl 4-isocyanatobenzoate 

Downstream Products

• 1031036-81-3 4-[5-(ethoxycarbonyl)-6-methyl-2-oxo-4-phenyl-3,4-dihydropyrimidin-1(2H)-yl]benzoic acid 
• 1562660-86-9 4-[6-methyl-5-(morpholin-4-ylcarbonyl)-2-oxo-4-phenyl-3,4-dihydropyrimidin-1(2H)-yl]benzoic acid 
• 13289-38-8 N-(4-carbethoxyphenyl)urea 
• 101101-89-7 4-(3-benzylidene-hydrazinocarbonylamino)-benzoic acid 
• 103797-73-5 4-(3-isopropylidene-hydrazinocarbonylamino)-benzoic acid 
• 100950-34-3 (+/-)-4-[3-(3-methyl-cyclohexylidene)-hydrazinocarbonylamino]-benzoic acid 
• 100950-34-3 4-[3-((S)-3-methyl-cyclohexylidene)-hydrazinocarbonylamino]-benzoic acid 
• 116433-06-8 C₃₂H₂₈N₆O₁₀S 
• 873-74-5 4-Aminobenzonitrile 
• 73469-95-1 4-(hydrazinecarboxamido)benzoic acid 
• 100949-12-0 3-nitro-4-(N'-nitro-ureido)-benzoic acid 

Relevant articles and documents

NOVEL CYSTOBACTAMIDE DERIVATIVES

The present invention relates to novel derivatives of cystobactamides of formula (lb) and the use thereof for the treatment or prophylaxis of bacterial infections.

Conventional and Microwave-Activated the Synthesis of a Novel Series of Imidazoles, Pyrimidines, and Thiazoles Candidates

A novel series of imidazoles, pyrimidines, and thiazoles were synthesized using microwave irradiation and conventional method from commercial available p-aminobenzoic acid. Thus, one-pot condensation of p-aminobenzoic acid, urea, and chloroacetic acid have been provided two types of imidazole derivatives as separated mixture 2a and 2b. [3?+?2?+?1] Cyclocondensation of 2a, benzaldehyde, and urea/thiourea in acidic medium afforded imidazolo oxazine derivative 3 and Imidazolothiazine 4. Coupling of 2a with benzene diazonium salt gave the phenyldiazenyl imidazolidine 5. While the reaction of 2a, thiourea, and benzaldehyde in sodium ethoxide afforded imidazolothiazine 6. Oxidative cyclization of thiourea derivative 7 resulted a mixture of benzithiazole derivative 7a and oxathiazole derivative 7b. Cyclocondensation of 7a with phenylenediamine and 4-methyl phenylenediamine furnished imidazole 8 and 9, respectively. Reaction of P-aminobenzioc acid with potassium cyanate followed by Biginelli reaction with (acetyl acetone, ethyl acetoacetate, and diethyl malonate) and salicyladehyde in HCl tolerated pyrimidine derivatives 10a–c, respectively. In the same manner, the reactions and short reaction time make microwave technique one of the greenest methodology for synthesis of this class of heterocyclic system.

Synthesis and biological activity evaluation of novel imidazolidinedione derivatives, as potent antidiabetic agent

A set of novel imidazolidinedione derivatives were synthesized and evaluated as potential antidiabetic agents. Imidazolidinedione scaffold-based molecules were synthesized and validated on a mice hyperglycemia model caused by alloxan. As a result, three of them showed antihyperglycemic activities. This research provides useful clues for further design and discovery of antidiabetic agents.