73469-95-1Relevant academic research and scientific papers
Design and development of novel p-aminobenzoic acid derivatives as potential cholinesterase inhibitors for the treatment of Alzheimer's disease
Shrivastava, Sushant K.,Sinha, Saurabh K.,Srivastava, Pavan,Tripathi, Prabhash N.,Sharma, Piyoosh,Tripathi, Manish K.,Tripathi, Avanish,Choubey, Priyanka K.,Waiker, Digambar K.,Aggarwal, Lalit M.,Dixit, Manish,Kheruka, Subhash C.,Gambhir, Sanjay,Shankar, Sharmila,Srivastava, Rakesh K.
, p. 211 - 223 (2018/10/21)
Based on the quantitative structure-activity relationship (QSAR), some novel p-aminobenzoic acid derivatives as promising cholinesterase enzyme inhibitors were designed, synthesized, characterized and evaluated to enhance learning and memory. The in vitro
Facile one-pot synthesis of 4-substituted semicarbazides
Bogolubsky, Andrey V.,Moroz, Yurii S.,Mykhailiuk, Pavel K.,Dmytriv, Yurii V.,Pipko, Sergey E.,Babichenko, Liudmyla N.,Konovets, Anzhelika I.,Tolmachev, Andrey
, p. 1063 - 1069 (2015/02/18)
A diverse library of twenty-five 4-mono- and disubstituted semicarbazides was prepared in a one-pot two-step approach. The method includes formation of a carbamate from bis(2,2,2-trifluoroethyl)carbonate or 2,2,2-trifluoroethylchloroformate and a primary or secondary amine and subsequent interaction of the carbamate with hydrazine to result in a semicarbazide. The approach allowed to obtain 4-substituted semicarbazides on a large scale in good yield and high purity. This journal is
