6306-30-5

Upstream product

• 799781-71-8 2-methyl-1-phenyl-pentane-1,2-diol 
• 106-94-5 propyl bromide 
• 103-79-7 1-phenyl-acetone 
• 107-08-4 1-iodo-propane 
• 27059-40-1 (1-chlorobutyl)benzene 
• 108-24-7 acetic anhydride 
• 917-64-6 methyl magnesium iodide 
• 7664-93-9 sulfuric acid 
• 20247-89-6 cis/trans-2-phenyl-hex-2-ene 
• 7782-25-4 (S)-(+)-2-phenylvaleric acid 
• 917-54-4 methyllithium 

Downstream Products

• 112624-66-5 1-morpholino-4-phenyl-heptan-3-one; hydrochloride 
• 54718-33-1 3,3-Diphenyl-2-hexanone 
• 73862-62-1 3-(4-Nitro-phenyl)-3-phenyl-hexan-2-one 
• 609815-91-0 Trimethyl-((E)-1-methyl-2-phenyl-pent-1-enyloxy)-silane 
• 252975-36-3 selenophosphoric acid Se-(1-acetyl-1-phenylbutyl) ester O,O-diethyl ester 
• 252975-27-2 thiophosphoric acid S-(1-acetyl-1-phenyl-butyl) ester O,O'-diethyl ester 
• 120625-70-9 C₁₉H₂₀N₄O₆ 

Relevant academic research and scientific papers

Dynamic Reductive Kinetic Resolution of Benzyl Ketones using Alcohol Dehydrogenases and Anion Exchange Resins

Dynamic reductive kinetic resolutions of racemic 3-arylalkanones have been performed by the proper combination of an alcohol dehydrogenase and a basic anionic resin. The best results were found for the bioreduction with the alcohol dehydrogenase type A from Rhodococcus ruber DSM 44541 overexpressed in Escherichia coli (E. coli/ADH-A) and the commercially available evo-1.1.200, while the Amberlite IRA-440 C and the DOWEX-MWA-1 resins allowed efficient in situ racemizations. Reaction conditions were optimized in terms of enzyme source and loading, type and amount of resin, pH, temperature and reaction times, obtaining a series of (R,R)-substituted propan-2-ols with good conversions and both diastereoselectivity and stereoselectivity. As a proof of concept, the subsequent intramolecular cyclization of a selected propan-2-ol substrate afforded a valuable isochroman heterocycle without any loss of the optical purity.

Oxidative rearrangements of arylalkenes with [hydroxy(tosyloxy)iodo]benzene in 95% methanol: A general, regiospecific synthesis of α-aryl ketones

The treatment of arylalkenes with [hydroxy(tosyloxy)iodo]benzene in 95% methanol affords the corresponding α-aryl ketones. This oxidative rearrangement is general for acyclic and cyclic arylalkenes and permits regioselective syntheses of isomeric α-phenyl ketone pairs.

Electroreductive Acylation of Benzyl Chlorides with Acid Anhydrides. Stereoselective Formation of (E)-Enol Esters from Benzyl Alkyl Ketones

Electroreduction of benzyl chlorides in the presence of acid anhydrides brought about stereoselective formation of (E)-enol esters of the corresponding benzyl alkyl ketones, the initial acylated products, in good to moderate yields.