27059-40-1

Basic information

• Product Name: Benzene, (1-chlorobutyl)-
• CAS NO: 27059-40-1
• Molecular Formula: C10H13Cl
• Molecular Weight: 168.666
• Mol File: 27059-40-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzene, (1-chlorobutyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, (1-chlorobutyl)-(27059-40-1)
• EPA Substance Registry System: Benzene, (1-chlorobutyl)-(27059-40-1)

Safety Data

• Hazardous Substances Data: 27059-40-1(Hazardous Substances Data)

Upstream product

• 614-14-2 1-Phenyl-1-butanol 
• 187737-37-7 propene 
• 35364-99-9 α-chlorobenzyl methyl ether 
• 75-71-8 Dichlorodifluoromethane 
• 104-51-8 1-butylbenzene 
• 495-40-9 propiophenone 
• 105854-98-6 1-phenyl-1-(phenylthio)butane 
• 13606-95-6 N-(pyridin-2-yl)butyramide 
• 5123-13-7 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane 

Downstream Products

• 614-14-2 1-Phenyl-1-butanol 
• 64985-90-6 meso-4,5-diphenyloctane 
• 42117-21-5 dl-4,5-diphenyloctane 
• 42117-21-5 C₂₀H₂₆ 
• 6306-30-5 3-phenyl-2-hexanone 
• 104-51-8 1-butylbenzene 
• 1560-06-1 1-phenyl-2-butene 
• 4397-69-7 (1-deuteriobutyl)benzene 
• 100874-73-5 N-butyl-1-phenylbutan-1-amine 
• 120357-05-3 4-(4-Fluorobenzoyl)-1-(4-phenylbutyl)piperidine 
• 84473-31-4 4-(Bromobutyl)benzene 
• 93536-66-4 2-Methyl-4-phenyl-hepten-⁽²⁾ 
• 132515-10-7 (+/-)-4-phenyl-heptan-3-one 
• 74338-67-3 2-(1-Phenyl-butyl)-cyclohexanone 

Relevant articles and documents

Indium-Catalyzed Formal Carbon-Halogen Bond Insertion: Synthesis of α-Halo-α,α-disubstituted Esters from Benzylic Halides and Diazo Esters

One-carbon-unit insertion into carbon-halogen (C-X) bonds accompanied by the formation of a new C-X bond and carbon-chain elongation is a powerful synthetic method of complex organohalides. Herein, we developed an indium trihalide catalyzed formal insertion of diazo esters into a C-X (X = Cl, Br, I) bond. In the present system, the reactions of α-aryl diazo esters with benzylic chlorides, bromides, and iodides yielded α-chloro, α-bromo, and α-iodo esters, respectively.

Ruthenium-Catalyzed Reductive Arylation of N-(2-Pyridinyl)amides with Isopropanol and Arylboronate Esters

A new three-component reductive arylation of amides with stable reactants (iPrOH and arylboronate esters), making use of a 2-pyridinyl (Py) directing group, is described. The N-Py-amide substrates are readily prepared from carboxylic acids and PyNH2, and the resulting N-Py-1-arylalkanamine reaction products are easily transformed into the corresponding chlorides by substitution of the HN-Py group with HCl. The 1-aryl-1-chloroalkane products allow substitution and cross-coupling reactions. Therefore, a general protocol for the transformation of carboxylic acids into a variety of functionalities is obtained. The Py-NH2 by-product can be recycled.

Desulfurative Chlorination of Alkyl Phenyl Sulfides

The chlorination of readily available secondary and tertiary alkyl phenyl sulfides using (dichloroiodo)benzene (PhICl2) is reported. This mild and rapid nucleophilic chlorination is extended to sulfa-Michael derived sulfides, affording elimination-sensitive β-chloro carbonyl and nitro compounds in good yields. The chlorination of enantioenriched benzylic sulfides to the corresponding inverted chlorides proceeds with high stereospecificity, thus providing a formal entry into enantioenriched chloro-Michael adducts. A mechanism implying the formation of a dichloro-λ4-sulfurane intermediate is proposed.