6306-61-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Propanamine, N-(2-chloroethyl)-, hydrochloride is used as an intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be incorporated into the development of new drugs, contributing to the advancement of medical treatments.
Used in Pesticide Industry:
In the pesticide industry, 2-Propanamine, N-(2-chloroethyl)-, hydrochloride is utilized as a key component in the production of certain pesticides. Its properties enable it to be an effective ingredient in controlling and managing pests, thereby supporting agricultural productivity.
Used as a Reagent in Organic Chemistry:
2-Propanamine, N-(2-chloroethyl)-, hydrochloride also serves as a reagent in the preparation of various organic compounds. Its versatility in chemical reactions makes it a valuable tool for researchers and chemists in the field of organic chemistry, facilitating the synthesis of a wide range of compounds for various applications.

InChI:InChI=1/C5H12ClN/c1-5(2)7-4-3-6/h5,7H,3-4H2,1-2H3

Upstream product

• 109-56-8 i-propyl(2-(hydroxy)ethyl)amine 

Downstream Products

• 1431869-88-3 C₂₄H₂₇F₂N₇O₂ 
• 1431869-90-7 C₂₄H₂₇F₂N₇O₂ 
• 1431869-78-1 C₂₄H₂₉N₇O₂ 
• 1431929-68-8 C₂₆H₂₉F₂N₅O₂ 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of 4-amino-5-chloro-N-(1,4- dialkylhexahydro-1,4-diazepin-6-yl)-2-methoxybenzamide derivatives, novel and potent serotonin 5-HT3 and dopamine D2 receptors dual antagonist

In search of a dopamine D2 and serotonin 5-HT3 receptors dual antagonist as a potential broad antiemetic agent, a number of benzamides were prepared from 4-amino-5-chloro-2-methoxybenzoic acid derivatives and 6-amino-1,4-dialkylhexahydro-1,4-diazepines and evaluated for their binding affinity for the dopamine D2 and the serotonin 5-HT3 receptors using rat brain synaptic and rat cortical membranes, respectively. From the results of both in vitro receptor binding and in vivo biological assays for the dopamine D2 receptor, 1-ethyl-4-methylhexahydro-1,4- diazepine ring was selected as an optimum amine moiety. Introduction of one methyl group on the nitrogen atom at the 4-position and/or modification of the substituent at the 5-position of the 4-amino-5-chloro-2-methoxybenzoyl moiety caused a marked increase in the dopamine D2 receptor binding affinity along with a potent 5-HT3 receptor binding affinity. Among the compounds, 5-chloro-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-2-methoxy-4- methylaminobenzamide (82), 5-bromo (110), and 5-iodo (112) analogues exhibited a much higher affinity for the dopamine D2 receptor than that of metoclopramide (IC50=17.5-61.0 nM vs. 483 nM). In particular, 82 showed a potent antagonistic activity for both receptors in vivo tests. Optical resolution of the racemate 82 brought about a dramatic change in the pharmacological profile with the (R)-enantiomer exhibiting a strong affinity for both the dopamine D2 and the 5-HT3 receptors, while the corresponding (S)-enantiomer had a potent and selective serotonin 5-HT 3 receptor binding affinity.