63095-84-1

Usage

Uses

Used in Pharmaceutical Industry:
N-methyl-2-(methylamino)propanamide is used as a building block for the synthesis of various drugs and active pharmaceutical ingredients. Its unique chemical structure allows it to be a versatile component in the development of new medications.
Used in Organic Synthesis:
N-methyl-2-(methylamino)propanamide is also used as a reagent in organic synthesis, where it can participate in various chemical reactions to form new compounds or modify existing ones.
Used in Industrial Chemical Production:
N-methyl-2-(methylamino)propanamide serves as a precursor in the production of various industrial chemicals, contributing to the manufacturing of a wide range of products across different industries.

InChI:InChI=1/C5H12N2O/c1-4(6-2)5(8)7-3/h4,6H,1-3H3,(H,7,8)

Upstream product

• 74-89-5 methylamine 
• 535-11-5 Ethyl 2-bromopropionate 
• 5445-17-0 Methyl 2-bromopropionate 
• 56428-90-1 ethyl-α-methylaminopropionate 
• 51784-00-0 3,4-dimethyl-oxazolidine-2,5-dione 

Downstream Products

• 63095-85-2 {1-[Methyl-(1-methylcarbamoyl-ethyl)-carbamoyl]-vinyl}-carbamic acid benzyl ester 

Relevant academic research and scientific papers

The gem-dimethyl effect on reactivities in cyclizations through tetrahedral intermediates. Cyclization of methyl-substituted methyl amides of 5-(p-nitrophenyl)hydantoic acids

The cyclization of the title hydantoinamides, UA, to 3-(4-nitrophenyl)hydantoins, Hyd, is general-base catalysed. Reversible hydrolysis of the product hydantoin from the 2,3-dimethylhydantoinamide, 2-UA, above pH = 7 is a complicating feature. The rate profiles for cyclization comprise one acid-catalysed, two neutral and two hydroxide-catalysed regions in the pH-region 0-10. Solvent kinetic isotope effects indicate rate-determining expulsion of the methylamino group in the acid-catalysed reaction. These also agree with general-base catalysis at low pH being concerted with nucleophillic attack of the ureido group. At high pH the tetrahedral intermediate is in equilibrium with the reactants and the rate is limited by proton transfers producing T±. The accelerations upon methyl substitution vary strongly with the various processes observed and may be explained in terms of a general gem-dimethyl effect increasing along the reaction coordinate from reagent through cyclic tetrahedral intermediate to final ring product. As the effects for the breakdown of the intermediate are opposite in the forward and reverse directions, this changes the partitioning ratio and in turn could change the rate-determining step.

Aminoamidines 6*. 4-Oxo- and 4-imino-1,3,2-diazaphospholanes and 4-imino-1,3,2-diazaphosphorinanes

reactions of N-aryl- and N-methyl-amidines and -amides of α-amino acids with RPCl2 afforded 4-aryl(methyl)imino and 4-oxo-1,3,2-diazaphospholanes. 4-Phenylimino-1,3,2-diazaphosphorinane was obtained in a similar way by the interaction of N(1),N(2)-dipheny

ENANTIOMERIC QUANTIFICATIONS OF AMINO ACIDS THROUGH THEIR Nα-ACYL AMIDES BY GAS CHROMATOGRAPHY.

Apparent separation of 1.1 or higher on Chiralsil Val III can be obtained for Nα-acyl N-alkyl aminoacid amides allowing the use of short capillary gas chromatographic columns.A clean derivatization protocol without racemization is described, proceding through the NCA derivatives that are prepared from "in situ" silylated amino acids with trimethylsilyl cyanide.