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Diethyl bis(hydroxymethyl)malonate is a versatile ester compound that serves as a key reagent in the synthesis of a variety of organic compounds, particularly within the pharmaceutical and agrochemical industries. Characterized by its unique structure and reactivity, Diethyl bis(hydroxymetyl)malonate is renowned for its ability to engage in reactions with diverse nucleophiles, such as amines and alcohols, to produce an array of functionalized derivatives. Its chemical properties render it an invaluable asset in the design and creation of novel organic molecules with potential biological activities.

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  • 631-23-2 Structure
  • Basic information

    1. Product Name: Diethyl bis(hydroxymetyl)malonate
    2. Synonyms: Diethyl bis(hydroxymetyl)malonate;2,2-Dihydroxypropanedioic acid 1,3-diethyl ester;2,2-dihydroxymalonic acid diethyl ester
    3. CAS NO:631-23-2
    4. Molecular Formula: C7H12O6
    5. Molecular Weight: 192.17
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 631-23-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 351.3 °C at 760 mmHg
    3. Flash Point: 134.5 °C
    4. Appearance: /
    5. Density: 1.315
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Diethyl bis(hydroxymetyl)malonate(CAS DataBase Reference)
    10. NIST Chemistry Reference: Diethyl bis(hydroxymetyl)malonate(631-23-2)
    11. EPA Substance Registry System: Diethyl bis(hydroxymetyl)malonate(631-23-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 631-23-2(Hazardous Substances Data)

631-23-2 Usage

Uses

Used in Pharmaceutical Industry:
Diethyl bis(hydroxymethyl)malonate is utilized as a synthetic intermediate for the preparation of complex molecules with potential therapeutic applications. Its reactivity with nucleophiles allows for the creation of a broad spectrum of functionalized derivatives, contributing to the development of new drugs with enhanced efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical sector, Diethyl bis(hydroxymethyl)malonate is employed as a building block for the synthesis of various agrochemicals, including pesticides and herbicides. Its ability to form a wide range of functionalized derivatives enables the design of innovative compounds with improved performance and selectivity in agricultural applications.
Used in Organic Synthesis:
Diethyl bis(hydroxymethyl)malonate is used as a versatile reagent in organic synthesis for the preparation of complex organic molecules. Its unique structure and reactivity make it a valuable tool for chemists to construct diverse molecular architectures with potential applications in various fields, such as materials science, catalysis, and medicinal chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 631-23-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,3 and 1 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 631-23:
(5*6)+(4*3)+(3*1)+(2*2)+(1*3)=52
52 % 10 = 2
So 631-23-2 is a valid CAS Registry Number.

631-23-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name Diethyl bis(hydroxymethyl)malonate

1.2 Other means of identification

Product number -
Other names dihydroxy-fumaric acid,dihydrate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:631-23-2 SDS

631-23-2Upstream product

631-23-2Relevant articles and documents

Facile synthesis of 1,2,3-tricarbonyls from 1,3-dicarbonyls mediated by cerium(IV) ammonium nitrate

Sivan, Akhil,Deepthi, Ani

supporting information, p. 1890 - 1893 (2014/03/21)

A mild and efficient protocol for the synthesis of vicinal tricarbonyl compounds from β-dicarbonyls in a single step using cerium(IV) ammonium nitrate as a catalytic oxidant is described. Ease of execution, wide substrate scope and the suitability for the synthesis of commercially important compounds like ninhydrin, alloxan and oxoline make this reaction particularly noteworthy.

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