631-87-8

Basic information

• Product Name: retinyl stearate
• Synonyms: retinyl stearate;Retinol stearate;all-trans-Retinyl Stearate;Retinol 15-Octadecanoate;Retinol Octadecanoate
• CAS NO: 631-87-8
• Molecular Formula: C₃₈H₆₄O₂
• Molecular Weight: 552.91
• Product Categories: Fatty Acid Derivatives & Lipids;Glycerols;Intermediates & Fine Chemicals;Pharmaceuticals;Retinoids
• Mol File: 631-87-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 628.7°C at 760 mmHg
• Flash Point: 71.2°C
• Appearance: /
• Density: 0.916g/cm³
• Vapor Pressure: 1.01E-15mmHg at 25°C
• Refractive Index: 1.505
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Hexanes (Slightly)
• Stability: Light Sensitive
• CAS DataBase Reference: retinyl stearate(CAS DataBase Reference)
• NIST Chemistry Reference: retinyl stearate(631-87-8)
• EPA Substance Registry System: retinyl stearate(631-87-8)

Safety Data

• Hazardous Substances Data: 631-87-8(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Oil

Uses

all-trans-Retinyl Stearate is used for the preparation of cosmetic and dermatological compositions.

Definition

ChEBI: A fatty acid ester formed between stearic acid and all-trans-retinol.

InChI:InChI=1/C38H64O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-27-37(39)40-32-30-34(3)25-22-24-33(2)28-29-36-35(4)26-23-31-38(36,5)6/h22,24-25,28-30H,7-21,23,26-27,31-32H2,1-6H3/b25-22+,29-28+,33-24+,34-30+

Upstream product

• 127-47-9 Retinol acetate 
• 57-11-4 stearic acid 
• 110-86-1 pyridine 
• 68-26-8 RETINOL 
• 112-76-5 Stearoyl chloride 

Relevant articles and documents

An LC/MS/MS method for stable isotope dilution studies of β-carotene bioavailability, bioconversion, and vitamin A status in humans

Isotope dilution is currently the most accurate technique in humans to determine vitamin A status and bioavailability/ bioconversion of provitamin A carotenoids such as α -carotene. However, limits of MS detection, coupled with extensive isolation procedures, have hindered investigations of physiologically-relevant doses of stable isotopes in large intervention trials. Here, a sensitive liquid chromatography- tandem mass spectrometry (LC/MS/MS) analytical method was developed to study the plasma response from coadministered oral doses of 2 mg [ 13 C 10 ] α -carotene and 1 mg [ 13 C 10 ]retinyl acetate in human subjects over a 2 week period. A reverse phase C 18 column and binary mobile phase solvent system separated α -carotene, retinol, retinyl acetate, retinyl linoleate, retinyl palmitate/retinyl oleate, and retinyl stearate within a 7 min run time. Selected reaction monitoring of analytes was performed under atmospheric pressure chemical ionization in positive mode at m/z 537 ? 321 and m/z 269 ? 93 for respective [ 12 C] α -carotene and [ 12 C] retinoids; m/z 547 ? 330 and m/z 274 ? 98 for [ 13 C 10 ] α -carotene and [ 13 C 5 ] cleavage products; and m/z 279 ? 100 for metabolites of [ 13 C 10 ]retinyl acetate. A single one-phase solvent extraction, with no saponification or purification steps, left retinyl esters intact for determination of intestinally-derived retinol in chylomicrons versus retinol from the liver bound to retinol binding protein. Coadministration of [ 13 C 10 ] retinyl acetate with [ 13 C 10 ] α -carotene not only acts as a reference dose for inter-individual variations in absorption and chylomicron clearance rates, but also allows for simultaneous determination of an individual's vitamin A status. - Oxley, A., P. Berry, G. A. Taylor, J. Cowell, M. J. Hall, J. Hesketh, G. Lietz, and A. V. Boddy. An LC/MS/MS method for stable isotope dilution studies of α -carotene bioavailability, bioconversion, and vitamin A status in humans. Copyright