6312-36-3

Usage

Physical state

White crystalline solid

Common use

Organic synthesis and pharmaceutical research

Type of compound

Ketone derivative

Structural features

a. Two phenyl groups attached to the carbon backbone
b. Amino group linked to an ethyl group

Applications

a. Production of pharmaceutical drugs
b. Development of new materials and chemical processes

Role in chemical synthesis

Versatile building block

Additional use

Reagent in organic reactions

Pharmacological significance

Potential pharmacological activity and importance in drug discovery and development

Upstream product

• 68100-24-3 1,2-diphenyl-2-(1-phenylethylimino)ethanone 

Downstream Products

• 77789-96-9 N-(Phenylethyl)-1,2-diphenyl-2-aminoethanol 
• 77789-95-8 N-(Phenylethyl)-1,2-diphenyl-2-aminoethanol 
• 82032-22-2 N-(Phenylethyl)-1-phenyl-1-benzoylmethylamine hydrochloride 
• 71690-12-5 1,2-Diphenyl-2-(1-phenyl-ethylamino)-ethanol 

Relevant academic research and scientific papers

Stereochemistry of Imino Group Reduction. 2. Synthesis and Assignment of Configuration of Some N-(1-Phenylethyl)-1,2-diaryl-2-aminoethanols.

Lithium aluminum hydride reduction of the monoimines prepared by reaction of benzils and 1-phenylethylamine yields a mixture of the related diastereomeric N-(1-phenethyl)-1,2-diaryl-2-aminoethanols.After separation of the diastereomers, assignment of their configuration is made on the basis of their infrared and NMR spectra.Catalytic hydrogenation of the monoimine prepared from benzil yields the amino ketone, which when treated with lithium aluminum hydride yields a mixture of aminoethanols.The composition of this shows that the stereochemical result of this reduct-ion is different from that of the direct reduction.Stereochemical results are analyzed on he basis of models which take into account different initial conformations of the monoimine and the higher probability of attack of hydride at the less hindered side of each conformer.