77789-96-9

Upstream product

• 1689-71-0 2,3-diphenyloxirane 
• 618-36-0 rac-methylbenzylamine 
• 6312-36-3 N-(Phenylethyl)-1-phenyl-1-benzoylmethylamine 
• 68100-24-3 1,2-diphenyl-2-(1-phenylethylimino)ethanone 
• 82032-22-2 N-(Phenylethyl)-1-phenyl-1-benzoylmethylamine hydrochloride 

Relevant academic research and scientific papers

CONFIGURATIONAL ASSIGNMENT TO N-(1-PHENYLALKYL)-SUBSTITUTED 2-AMINO-1,2-DIPHENYLETHANOLS

Three-chiral centre aminoethanols are obtained by reduction of 1,2-imino ketones having a preexistenting chiral centre.Assignment of configuration to the aminoethanols has been carried out on the basis of high-dilution i.r., 1H n.m.r., and 13C n.m.r. spectroscopic data.

THE STEREOSELECTIVE REDUCTION OF α-AMINODEOXYBENZOIN DERIVATIVES WITH SODIUM BOROHYDRIDE

Total stereoselectivity is observed in the sodium borohydride reduction of α-aminodeoxybenzoins and their hydrochlorides in various hydroxylic solvents.RS-SR isomer (erythro) was the only aminoalcohol obtained.

Stereochemistry of Imino Group Reduction. 2. Synthesis and Assignment of Configuration of Some N-(1-Phenylethyl)-1,2-diaryl-2-aminoethanols.

Lithium aluminum hydride reduction of the monoimines prepared by reaction of benzils and 1-phenylethylamine yields a mixture of the related diastereomeric N-(1-phenethyl)-1,2-diaryl-2-aminoethanols.After separation of the diastereomers, assignment of their configuration is made on the basis of their infrared and NMR spectra.Catalytic hydrogenation of the monoimine prepared from benzil yields the amino ketone, which when treated with lithium aluminum hydride yields a mixture of aminoethanols.The composition of this shows that the stereochemical result of this reduct-ion is different from that of the direct reduction.Stereochemical results are analyzed on he basis of models which take into account different initial conformations of the monoimine and the higher probability of attack of hydride at the less hindered side of each conformer.