63132-77-4Relevant academic research and scientific papers
HSP90 INHIBITORS
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Page/Page column 183, (2012/10/18)
The disclosure relates to Compounds of Formulae (IA) and (IB), and pharmaceutically acceptable salts thereof wherein Z1, Z2, Z3, Xa, Xb, Xc, Xd, Y, X2, and X4 are as defined herein, compositions comprising an effective amount of a Compound of Formula (IA) and/or (IB), and methods to treat or prevent a condition, such cancer which overexpresses Her-kinases, comprising administering to an patient in need thereof a therapeutically effective amount of a Compound of Formula (IA) or (IB). The disclosure further relates to compounds of Formulae (IA) and (IB) in which X2 is a leaving for introducing a radiolabeled atom, such as 124I or 131I and to methods of using such compounds in the preparation of radiolabeled compounds, particularly for use in imaging.
Identification of a novel RAMP-independent CGRP receptor antagonist
Zartman, C. Blair,Bell, Ian M.,Gallicchio, Steven N.,Graham, Samuel L.,Kane, Stefanie A.,Mallee, John J.,Rutledge, Ruth Z.,Salvatore, Christopher A.,Vacca, Joseph P.,Williams, Theresa M.
scheme or table, p. 6705 - 6708 (2011/12/21)
Identification of an HIV integrase inhibitor with micromolar affinity for the CGRP receptor led to the discovery of a series of structurally novel CGRP receptor antagonists. Optimization of this series produced compound 16, a low-molecular weight CGRP rec
Practical Synthesis of Sultams via Sulfonamide Dianion Alkylation: Application to the Synthesis of Chiral Sultams
Lee, Jaemoon,Zhong, Yong-Li,Reamer, Robert A.,Askin, David
, p. 4175 - 4177 (2007/10/03)
(Equation presented) A practical synthesis of sultams was developed via intramolecular sulfonamide dianion alkylation. This method has been applied toward the synthesis of chiral sultams, which are synthetically valuable as chiral auxiliaries.
Sulfonamide herbicide antidote compositions and method of use
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, (2008/06/13)
Herbicidal compositions consisting of an active herbicidal compound and an antidote therefor and the methods of use of the herbicide compositions are described herein. The antidote compound corresponds to the formula STR1 wherein R1 can be sele
