63139-16-2 Usage
General Description
Withanolides are a group of naturally occurring steroidal compounds found in plants of the Solanaceae family, particularly in the roots and leaves of the Withania somnifera, commonly known as ashwagandha. These compounds are characterized by their complex and diverse chemical structures, and are known for their therapeutic properties, including anti-inflammatory, antioxidant, and immunomodulatory effects. Withanolides have been studied for their potential to improve physical and mental health, including their ability to reduce stress, anxiety, and fatigue, as well as their potential in cancer treatment and anti-aging effects. Additionally, withanolides have shown potential for improving cognitive function and enhancing memory and learning abilities. These compounds have gained attention and are being researched for their potential applications in medicine, particularly in neurodegenerative diseases and stress-related disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 63139-16-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,1,3 and 9 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 63139-16:
(7*6)+(6*3)+(5*1)+(4*3)+(3*9)+(2*1)+(1*6)=112
112 % 10 = 2
So 63139-16-2 is a valid CAS Registry Number.
InChI:InChI=1/C28H40O8/c1-15-13-21(36-22(31)16(15)2)25(5,32)28(35)12-11-26(33)18-14-20(30)27(34)9-6-7-19(29)24(27,4)17(18)8-10-23(26,28)3/h6-7,17-18,20-21,30,32-35H,8-14H2,1-5H3
63139-16-2Relevant articles and documents
Synthetic Modifications of Withanolides with an α-Orientated Side-Chain
Glotter, Erwin,Kumar, Sandeep,Sahai, Mahendra,Goldman, Alex,Kirson, Isaac,Mendelovici, Marioara
, p. 739 - 745 (2007/10/02)
In view of the antitumour activity of withanolide E and 4β-hydroxywithanolide E, synthetically modified analogues were prepared.In these compounds, the α-orientation of the side-chain was retained.Its degree of bending with respect to the carbocyclic skeleton depends on the presence or absence of the 14α-OH group.Elimination of this group leads to the formation of the 14,20-oxido-bridged and Δ14-compounds.Epoxidation of the latter afforded 14α,15α-epoxides.With the exception of several 5,6-chlorohydrins, most compounds possess an epoxide ring, allylic or homoallylic with respect to the ring A enone.
